Investigating hemodynamic response variability at the group level using basis functions.

NeuroImage
Jason SteffenerYaakov Stern

Abstract

Introduced is a general framework for performing group-level analyses of fMRI data using any basis set of two functions (i.e., the canonical hemodynamic response function and its first derivative) to model the hemodynamic response to neural activity. The approach allows for flexible implementation of physiologically based restrictions on the results. Information from both basis functions is used at the group level and the limitations avoid physiologically ambiguous or implausible results. This allows for investigation of specific BOLD activity such as hemodynamic responses peaking within a specified temporal range (i.e., 4-5 s). The general nature of the presented approach allows for applications using basis sets specifically designed to investigate various physiologic phenomena, i.e., age-related variability in poststimulus undershoot, hemodynamic responses measured with cerebral blood flow imaging, or subject-specific basis sets. An example using data from a group of healthy young participants demonstrates the methods and the specific steps to study poststimulus variability are discussed. The approach is completely implemented within the general linear model and requires minimal programmatic calculations.

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Citations

Dec 20, 2012·PloS One·Clare PressGeoffrey Bird
Jul 19, 2013·PloS One·Xiaotong WenMingzhou Ding
Feb 19, 2011·Brain Research·Thilo KellermannUte Habel
Aug 24, 2012·Human Brain Mapping·Linda GeerligsMonicque M Lorist
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Jul 16, 2011·NeuroImage·Ronald SladkyChristian Windischberger
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Jul 26, 2018·Neuroscience of Consciousness·Gregor WilbertzPhilipp Sterzer
Aug 30, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·David M Lydon-StaleyDanielle S Bassett
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Jan 9, 2018·NeuroImage·Pranav G ReddyDanielle S Bassett
Sep 29, 2021·Journal of the Association for Research in Otolaryngology : JARO·Faizah MushtaqDouglas E H Hartley

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