Investigating molecular alterations to profile short- and long-term recurrence-free survival in patients with primary glioblastoma

Oncology Letters
Sara FranceschiAntonio G Naccarato

Abstract

Glioblastoma (GB) is the most aggressive type of primary brain tumor. Despite the progress in recent years regarding the diagnosis and treatment of GB, the recurrence rate remains high, due to the infiltrative and dispersive nature of the tumor, which typically results in poor patient prognosis. In the present study, 19 formalin-fixed, paraffin-embedded GB samples were selected from patients with GB tumors. The samples were classified into a short or long recurrence-free survival (RFS) group, based on the time of first recurrence of the disease in the patients. The 19 samples were molecularly characterized for mutations in the isocitrate dehydrogenase 1 (IDH1) gene, amplification of the epidermal growth factor receptor (EGFR) gene, presence of the EGFR variant III, and methylation of the promoter region of the O(6)-methylguanine-DNA methyltransferase (MGMT) gene. Then, the expression of 84 genes involved in cell-cell and cell-matrix interactions, and that of 84 microRNAs (miRNAs) associated with brain cancer, was profiled. In addition, a copy number variation analysis of 23 genes reported to undergo frequent genomic alterations in human glioma was also performed. Differences in the expression levels of a number of genes were de...Continue Reading

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Citations

Mar 26, 2016·Molecular Neurobiology·Dongsheng ZhaoZhou Fei
Jun 19, 2018·Applied Immunohistochemistry & Molecular Morphology : AIMM·Minju LeeYeon-Lim Suh
Aug 9, 2017·BioMed Research International·Nadia SenhajiSanae Bennis
Apr 14, 2020·Cancer Cell International·Xinli ZhaoXinzhong Zhang
May 12, 2020·Frontiers in Oncology·Giuseppe Nicolò FanelliCristian Scatena
Aug 28, 2019·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·O RiouD Azria
Jun 19, 2021·Biomedit︠s︡inskai︠a︡ khimii︠a︡·M P KalyaA Kel
Jul 31, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Mingjie QingLijuan Cheng

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