Abstract
Glioblastoma (GB) is the most aggressive type of primary brain tumor. Despite the progress in recent years regarding the diagnosis and treatment of GB, the recurrence rate remains high, due to the infiltrative and dispersive nature of the tumor, which typically results in poor patient prognosis. In the present study, 19 formalin-fixed, paraffin-embedded GB samples were selected from patients with GB tumors. The samples were classified into a short or long recurrence-free survival (RFS) group, based on the time of first recurrence of the disease in the patients. The 19 samples were molecularly characterized for mutations in the isocitrate dehydrogenase 1 (IDH1) gene, amplification of the epidermal growth factor receptor (EGFR) gene, presence of the EGFR variant III, and methylation of the promoter region of the O(6)-methylguanine-DNA methyltransferase (MGMT) gene. Then, the expression of 84 genes involved in cell-cell and cell-matrix interactions, and that of 84 microRNAs (miRNAs) associated with brain cancer, was profiled. In addition, a copy number variation analysis of 23 genes reported to undergo frequent genomic alterations in human glioma was also performed. Differences in the expression levels of a number of genes were de...Continue Reading
References
Mar 20, 1998·International Journal of Cancer. Journal International Du Cancer·J C KnottR Bjerkvig
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E T WongW K Yung
Aug 10, 2000·Neoplasia : an International Journal for Oncology Research·M E Berens, A Giese
Jan 10, 2002·Cell·V Ambros
Sep 18, 2004·Cancer Research·William A FreijeStanley F Nelson
Mar 11, 2005·The New England Journal of Medicine·Roger StuppUNKNOWN National Cancer Institute of Canada Clinical Trials Group
Mar 15, 2006·Cancer Cell·Heidi S PhillipsKen Aldape
May 20, 2006·Neurosurgical Focus·Lewis C HouVictor C K Tse
Jul 10, 2007·Acta Neuropathologica·David N LouisPaul Kleihues
Mar 22, 2008·Neuro-oncology·Kathleen R LambornUNKNOWN North American Brain Tumor Consortium
Dec 2, 2009·Cell Adhesion & Migration·Mei Chung Moh, Shali Shen
Apr 8, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Stuart A GrossmanUNKNOWN NABTT CNS Consortium
Sep 20, 2012·Cancer·Wei ZhangTao Jiang
Oct 19, 2012·PloS One·Zhifeng WuZhengxiang Yang
Dec 5, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hiroko Ohgaki, Paul Kleihues
Apr 10, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Andrej BesseOndrej Slaby
Oct 15, 2013·Blood Cancer Journal·S CaramutaW-O Lui
Dec 7, 2013·PloS One·Songyin HuangYandan Yao
Jan 24, 2014·PloS One·An-an YinXiang Zhang
Jun 4, 2014·BMC Medical Genomics·Rivka R ColenPascal O Zinn
Citations
Mar 26, 2016·Molecular Neurobiology·Dongsheng ZhaoZhou Fei
Jun 19, 2018·Applied Immunohistochemistry & Molecular Morphology : AIMM·Minju LeeYeon-Lim Suh
Aug 9, 2017·BioMed Research International·Nadia SenhajiSanae Bennis
Dec 5, 2019·International Journal of Molecular Sciences·Prospero CivitaGeoffrey J Pilkington
Dec 5, 2019·Cancer Cell International·Shuai WuJie Zhang
Dec 13, 2019·Cancer Cell International·Xizhao WangYe Song
Jan 25, 2019·Oncology Letters·Chang-You YinWei Zhao
Jun 25, 2019·Frontiers in Oncology·Prospero CivitaChiara Maria Mazzanti
Jan 1, 2020·Cancer Cell International·Lizhang HanLing Tang
Apr 14, 2020·Cancer Cell International·Xinli ZhaoXinzhong Zhang
May 12, 2020·Frontiers in Oncology·Giuseppe Nicolò FanelliCristian Scatena
Aug 28, 2019·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·O RiouD Azria
Jun 19, 2021·Biomedit︠s︡inskai︠a︡ khimii︠a︡·M P KalyaA Kel
Jul 3, 2021·Frontiers in Genetics·Manasa KalyaTim Beißbarth
Jul 31, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Mingjie QingLijuan Cheng