Investigating population continuity with ancient DNA under a spatially explicit simulation framework

BMC Genetics
Nuno Miguel SilvaMathias Currat

Abstract

Recent advances in sequencing technologies have allowed for the retrieval of ancient DNA data (aDNA) from skeletal remains, providing direct genetic snapshots from diverse periods of human prehistory. Comparing samples taken in the same region but at different times, hereafter called "serial samples", may indicate whether there is continuity in the peopling history of that area or whether an immigration of a genetically different population has occurred between the two sampling times. However, the exploration of genetic relationships between serial samples generally ignores their geographical locations and the spatiotemporal dynamics of populations. Here, we present a new coalescent-based, spatially explicit modelling approach to investigate population continuity using aDNA, which includes two fundamental elements neglected in previous methods: population structure and migration. The approach also considers the extensive temporal and geographical variance that is commonly found in aDNA population samples. We first showed that our spatially explicit approach is more conservative than the previous (panmictic) approach and should be preferred to test for population continuity, especially when small and isolated populations are con...Continue Reading

References

Sep 7, 2018·American Journal of Physical Anthropology·Michela LeonardiGuido Barbujani
Oct 23, 2018·Evolutionary Applications·Nuno Miguel SilvaMathias Currat
Dec 13, 2018·Heredity·Diego Ortega-Del Vecchyo, Montgomery Slatkin
Apr 22, 2020·Evolution Letters·Marianne DehasqueAndrew D Foote

Citations

Oct 1, 1991·Genetical Research·Montgomery Slatkin
Nov 24, 1998·International Journal of Legal Medicine·F Rousselet, P Mangin
Jan 10, 2003·Molecular Biology and Evolution·Nicolas RayLaurent Excoffier
Nov 27, 2004·Bioinformatics·Christian N K AndersonElizabeth A Hadly
May 5, 2005·Proceedings. Biological Sciences·Mathias Currat, Laurent Excoffier
May 17, 2006·Proceedings of the National Academy of Sciences of the United States of America·Elise M S BelleGuido Barbujani
Sep 18, 2008·Proceedings. Biological Sciences·Omkar DeshpandeL Luca Cavalli-Sforza
Dec 1, 2009·Human Biology·Andreas ZimmermannKarl Peter Wendt
Dec 4, 2009·Molecular Biology and Evolution·Silvia GhirottoGuido Barbujani
Jan 26, 2010·Molecular Biology and Evolution·Olivier FrançoisJohn Novembre
Nov 19, 2010·PLoS Biology·Wolfgang HaakMembers of the Genographic Consortium
May 14, 2011·Molecular Ecology Resources·Laurent Excoffier, Heidi E L Lischer
Mar 1, 2012·Genetics·Montgomery Slatkin, Laurent Excoffier
Jul 4, 2012·Current Biology : CB·Federico Sánchez-QuintoCarles Lalueza-Fox
Aug 28, 2012·Molecular Biology and Evolution·Miguel ArenasLaurent Excoffier
Feb 14, 2013·PloS One·Silvia GhirottoGuido Barbujani
Oct 12, 2013·Science·Ruth BollonginoJoachim Burger
Jan 1, 2013·Human Heredity·Marie-France Deguilloux, Fanny Mendisco
Jan 1, 2013·Human Heredity·Mathias Currat, Nuno M Silva
Aug 8, 2014·Molecular Biology and Evolution·Adrien RieuxFrançois Balloux
Oct 22, 2014·Nature Communications·Cristina GambaRon Pinhasi
Jun 9, 2016·Proceedings of the National Academy of Sciences of the United States of America·Zuzana HofmanováJoachim Burger
Mar 4, 2017·Scientific Reports·Alessandra ModiSilvia Ghirotto
Jul 4, 2017·Current Biology : CB·Ashot MargaryanMorten E Allentoft

Related Concepts

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