Investigating Subcellular Compartment Targeting Effect of Porous Coordination Cages for Enhancing Cancer Nanotherapy

Small
Yu FangHong-Cai Zhou

Abstract

Understanding the key factors for successful subcellular compartment targeting for cargo delivery systems is of great interest in a variety of fields such as bionanotechnology, cell biology, and nanotherapies. However, the fundamental basis for intracellular transportation with these systems has thus far rarely been discussed. As a cargo vector, porous coordination cages (PCCs) have great potential for use in cancer nanotherapy and to elucidate fundamental insight regarding subcellular compartment targeting. Herein, it is shown that the transportation of PCC cargo vectors though various subcellular barriers of the mammalian cell can be manipulated by tuning the vector's electronic property and surface affinity. It is found that the PCCs become selectively aggregated at the cell membrane, the cytoplasm, or the nucleus, respectively. When a DNA topoisomerase inhibitor is delivered into the nucleus by a neutral and lipophilic PCC, the anticancer efficacy is dramatically improved. The findings shed light to tune the interactions at the "bio-nano" interface. This study provides a key strategy for future work in targeting specific cell organelles for cell imaging, cargo delivery, and therapy. This research also offers key insight int...Continue Reading

References

Jan 1, 1987·Annual Review of Biochemistry·J W Newport, D J Forbes
Mar 1, 1985·The Journal of Cell Biology·P GreenspanS D Fowler
Feb 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·L V JohnsonL B Chen
Feb 1, 1967·The Journal of Cell Biology·J G Gall
Dec 26, 2001·Nature Biotechnology·Robert P BennettPamela M Guy
Sep 27, 2002·Current Opinion in Pharmacology·Mark A Lindsay
Oct 9, 2002·Current Drug Metabolism·Meihua Rose Feng
Aug 13, 2004·Proceedings of the National Academy of Sciences of the United States of America·Weidong YangSiegfried M Musser
Feb 3, 2005·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Jasmina LovrićDusica Maysinger
Apr 30, 2005·The Biochemical Journal·Catherine De CoupadeFrançoise Cailler
Jul 21, 2005·Technology in Cancer Research & Treatment·Jaspreet K Vasir, Vinod Labhasetwar
Jan 20, 2007·Science·Gretchen A DevriesFrancesco Stellacci
May 4, 2007·Accounts of Chemical Research·Pascale R LeroueilMark M Banaszak Holl
May 27, 2008·Nature Materials·Ayush VermaFrancesco Stellacci
Jul 26, 2008·Nature Nanotechnology·Kostas KostarelosAlberto Bianco
Sep 13, 2008·Trends in Cell Biology·Maximiliano A D'Angelo, Martin W Hetzer
Jun 27, 2009·Science·Prasenjit MalJonathan R Nitschke
Oct 28, 2010·Journal of the American Chemical Society·Jeffrey S MugridgeKenneth N Raymond
Jun 15, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·You Han Bae, Kinam Park
Sep 29, 2011·Topics in Current Chemistry·Bruno Therrien
Nov 3, 2011·Journal of the American Chemical Society·Rana A BilbeisiJonathan R Nitschke
Dec 16, 2011·Chemical Reviews·Patricia HorcajadaChristian Serre
Dec 22, 2011·Journal of the American Chemical Society·Frédéric SchmittBruno Therrien
Jan 4, 2012·Angewandte Chemie·Mei LiuHongjie Zhang
May 4, 2012·Journal of the American Chemical Society·Feng-Rong Dai, Zhenqiang Wang
Aug 9, 2012·Chemical Communications : Chem Comm·Shangchao DuWuping Liao
Nov 13, 2012·Journal of Hematology & Oncology·Michael A Firer, Gary Gellerman
Nov 13, 2012·Expert Opinion on Drug Delivery·Chun-Yi SunZhong-Min Su
Dec 29, 2012·Journal of the American Chemical Society·Yu FangMakoto Fujita
Mar 30, 2013·Cellular Logistics·Dipannita Dutta, Julie G Donaldson
May 4, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Sabina TaturGiovanna Fragneto
Sep 6, 2013·Cancer Cell International·Yasumasa KatoYuh Baba
May 3, 2014·Journal of the American Chemical Society·Feng-Rong DaiZhenqiang Wang
Jun 13, 2014·Journal of Medicinal Chemistry·Quan HuYu Yang
Jan 27, 2015·Chemical Science·Yao-Rong ZhengStephen J Lippard

❮ Previous
Next ❯

Citations

Jul 24, 2020·Journal of Drug Targeting·Zhijing HeGuangxi Zhai
Jul 6, 2021·Dalton Transactions : an International Journal of Inorganic Chemistry·Wen-Yuan PeiJian-Fang Ma
May 16, 2019·Journal of the American Chemical Society·Xiangquan HuJerry L Atwood
Nov 26, 2020·Chemical Reviews·Edmundo G PercásteguiJonathan R Nitschke
Oct 5, 2021·Dalton Transactions : an International Journal of Inorganic Chemistry·Haeri LeeOk-Sang Jung

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.

Related Papers

Deutsche medizinische Wochenschrift
Wiebke Kathmann
ACS Biomaterials Science & Engineering
Asiri Ediriwickrema, W Mark Saltzman
Journal of Peptide Science : an Official Publication of the European Peptide Society
Chaitali D DekiwadiaJohn V Fecondo
© 2022 Meta ULC. All rights reserved