Investigating T cell activation and tolerance in vivo: peptide challenge in allergic asthmatics

Cytokine
Trevor R F Smith, Mark Larché

Abstract

In the atopic allergic individual, challenge with allergen elicits manifestations of both the humoral (IgE-mediated or early-phase reaction) and the cell-mediated immune response (late-phase reaction). Detailed study of late-phase cell-mediated events is confounded by the effects of the earlier IgE-mediated response which results in mast cell and basophil activation. Thus the relative contributions to allergic inflammation of individual cell types, such as T cells and eosinophils, are difficult to define. In this review we describe experiments, largely from our own group, in which we have attempted to dissociate early and late allergic reactions. To this end, cell-mediated responses were induced in the absence of preceding IgE-mediated events, by the delivery of synthetic peptides representing T cell epitopes of the allergen. Activation of T cells resulted in airway narrowing and an increase in airway reactivity to non-specific stimuli. Furthermore, we describe the induction of antigen-specific hyporesponsiveness or "tolerance" following intradermal, but not mucosal, peptide delivery. The induction of peptide-induced hyporesponsiveness could be temporally dissociated from the initial T cell activation resulting in bronchoconstr...Continue Reading

References

Jun 7, 1994·Proceedings of the National Academy of Sciences of the United States of America·L VidardB Benacerraf
Nov 1, 1996·The Journal of Allergy and Clinical Immunology·C M CounsellR D Garman
Nov 1, 1996·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P G MarkR D Garman
Sep 23, 2003·American Journal of Respiratory and Critical Care Medicine·F Runa AliA Barry Kay

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Citations

Sep 22, 2006·Viral Immunology·Juan Manuel Alcocer-GonzálezVicente Madrid-Marina
Dec 1, 2005·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Ozlem KeskinBulent E Sekerel
Oct 22, 2008·Allergologia et immunopathologia·A J Lucendo
Dec 5, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J WallmannE Jensen-Jarolim
Jul 21, 2006·Allergologia et immunopathologia·M T Montero Vega

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