Investigating the association between body fat and depression via Mendelian randomization

Translational Psychiatry
M S SpeedS D Østergaard

Abstract

Obesity and depression are major public health concerns that are both associated with substantial morbidity and mortality. There is a considerable body of literature linking obesity to the development of depression. Recent studies using Mendelian randomization indicate that this relationship is causal. Most studies of the obesity-depression association have used body mass index as a measure of obesity. Body mass index is defined as weight (measured in kilograms) divided by the square of height (meters) and therefore does not distinguish between the contributions of fat and nonfat to body weight. To better understand the obesity-depression association, we conduct a Mendelian randomization study of the relationship between fat mass, nonfat mass, height, and depression, using genome-wide association study results from the UK Biobank (n = 332,000) and the Psychiatric Genomics Consortium (n = 480,000). Our findings suggest that both fat mass and height (short stature) are causal risk factors for depression, while nonfat mass is not. These results represent important new knowledge on the role of anthropometric measures in the etiology of depression. They also suggest that reducing fat mass will decrease the risk of depression, which ...Continue Reading

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Citations

May 12, 2020·Metabolic Syndrome and Related Disorders·Sevda Bag, Feray Akbas
May 20, 2020·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Hilde de KluiverBrenda W J H Penninx
Jun 18, 2020·Diseases·Walter MilanoAnna Capasso
Jan 19, 2021·The International Journal of Eating Disorders·Christina HorsagerSøren Dinesen Østergaard
Mar 31, 2021·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Baoshan MaJun Lv
May 4, 2020·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Niharika SamalaNaga Chalasani
Apr 30, 2021·Acta Psychiatrica Scandinavica·Hilde de KluiverBrenda W J H Penninx
Jun 1, 2021·Human Genetics·Luis M García-MarínMiguel E Rentería
Jun 6, 2021·Eating and Weight Disorders : EWD·Christina HorsagerSøren Dinesen Østergaard
Jul 17, 2021·Human Molecular Genetics·Francesco CasanovaJess Tyrrell

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Software Mentioned

R package Mendelian randomization

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