Jan 15, 2005

Investigating the effect of remodelling signal type on the finite element based predictions of bone remodelling around the thrust plate prosthesis: a patient-specific comparison

Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
M J SchmitzH Bereiter


The resorption of bone in the human femur following total hip arthroplasty is recognized to be related to the loading in the bone surrounding the prosthesis. However, the precise nature of the mechanical signal that influences the biological remodelling activity of the bone is not completely understood. In this study, a validated finite element modelling methodology was combined with a numerical algorithm to simulate the biological changes over time. This was used to produce bone remodelling predictions for an implanted thrust plate prosthesis (Centerpulse Orthopedics Limited) in a patient specific bone model. The analysis was then repeated using different mechanical signals to drive the remodelling algorithm. The results of these simulations were then compared to the patient-specific clinical data, to distinguish which of the candidate signals produced predictions consistent with the clinical evidence. Good agreement was found for a range of strain energy based signals and also deviatoric remodelling signals. The results, however, did not support the use of compressive dilatational strain as a candidate remodelling signal.

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Mentioned in this Paper

Hip Joint Implantable Prostheses (Device)
In Silico
Bone Resorption
Bone Plates
Entire Femur
Bone Remodelling Pathway
Mechanotransduction, Cellular
Finite Element Analysis
Prosthesis Survival

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