Investigating the effect of TiO2 on the structure and biocompatibility of bioactive glass

Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Lana M PlacekAnthony W Wren

Abstract

Titanium (Ti4+ ) containing materials have been widely used in medical applications due to its associated bioactivity in vivo. This study investigates the replacement of Si4+ with Ti4+ within the system SiO2 -Na2 O-CaO-P2 O5 to determine its influence on glass structure. This strategy was conducted in order to control the glass solubility to further improve the cellular response. Ti4+ incorporation was found to have little influence on the glass transition temperature (Tg  = 520 ± 8°C) and magic angle spinning-nuclear magnetic resonance (MAS-NMR) shifts (-80 ppm) up to additions of 18 wt %. However, at 30 wt % the Tg increased to 600°C and MAS-NMR spectra shifted to -88 ppm. There was also an associated reduction in glass solubility as a function of Ti4+ incorporation as determined by inductively coupled plasma optical emission spectroscopy where Si4+ (1649-44 mg/L) and Na+ (892-36 mg/L) levels greatly reduced while Ca2+ (3-5 mg/L) and PO43- (2-7 mg/L) levels remained relatively unchanged. MC3T3 osteoblasts were used for cell culture testing and it was determined that the Ti4+ glasses increased cell viability and also facilitated greater osteoblast adhesion and proliferation to the glass surface compared to the control glass. ©...Continue Reading

References

Oct 1, 1992·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J H AndersonC S McArdle
Jan 1, 1997·Journal of Biomedical Materials Research·Z L SunC T Hanks
Apr 18, 2003·Biomaterials·Tadashi KokuboMasakazu Kawashita
Dec 13, 2005·Biomaterials·Qizhi Z ChenAldo R Boccaccini
Feb 2, 2006·Biomaterials·Tadashi Kokubo, Hiroaki Takadama
Nov 24, 2006·Journal of Materials Science. Materials in Medicine·Larry L Hench
Nov 16, 2010·Journal of Materials Science. Materials in Medicine·A W WrenM R Towler
Mar 1, 2009·Metallomics : Integrated Biometal Science·Erwin Ph ChanLuis Filgueira
Aug 28, 2012·Acta Biomaterialia·Julian R Jones
Apr 30, 2013·Materials Science & Engineering. C, Materials for Biological Applications·Neda Saffarian TousiVenu G Varanasi
May 16, 2014·Journal of Biomedical Materials Research. Part a·Anthony W WrenMark R Towler

❮ Previous
Next ❯

Citations

Nov 26, 2019·Materials Science & Engineering. C, Materials for Biological Applications·Romina ShafaghiMark R Towler

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Biomedical Materials Research. Part a
Anthony W WrenMark R Towler
Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Klára MagyariViorica Simon
Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Gwenaelle VergnolDaniel J Hartmann
© 2021 Meta ULC. All rights reserved