Investigating the effects of treatment based on single high blood glucose in gestational diabetes screening on maternal and neonatal complications

Archives of Gynecology and Obstetrics
Masoumeh MirzamoradiMohammad Ali Mansournia

Abstract

To create a positive step toward achieving an efficient method for gestational diabetes treatment, the present study was carried out to compare the treatment outcomes based on single impaired blood glucose versus regular method in health care centers in Iran. This randomized clinical trial was carried out in Tehran/Iran between March 2012 and August 2013. Study sample consisted of mothers whose fasting blood sugar was disturbed or a disturbed blood sugar was seen in OGTT with 75 g glucose load, according to ADA standards. For each outcome, multiple logistic regressions were used to control for the effects of potential confounders. When a confounder was measured on a continuous scale (e.g., age), LOWESS (locally weighted scatter plot smoothing) algorithm was used to determine whether the effect of that variable was linear. We also used the fractional polynomial regression to determine the optimal transformation of continuous covariates. The information of 189 pregnant women was used in this study; 87 in the interventional group (46 %) and 102 in the control group (54 %). Treatment based on the new protocol has very high protective effect (OR 0.25, 95 % CI 0.68-0.88) in terms of neonatal hyperbilirubinemia. This difference was no...Continue Reading

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Citations

May 5, 2017·The Cochrane Database of Systematic Reviews·Julie BrownCaroline A Crowther
Jun 26, 2017·BMJ Open·Diane FarrarDebbie A Lawlor

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