Investigating the effects of TTS-fentanyl for cancer pain on the psychological status of patients naïve to strong opioids: an open label study

Cancer Nursing
Kyriaki MystakidouLambros Vlahos

Abstract

Few studies have investigated the effect of fentanyl delivered via the transdermal route with regard to the patient's psychological status. Patients who were naive to strong opioids and were attending a palliative care unit for pain relief from advanced cancer participated in this study to determine the effect of transdermal therapeutic system fentanyl (TTS-F) on their psychological condition. Spielberger State-Trait Anxiety Inventory (STAI), Zung Self-Rating Depression Scale (SDS), the Karnofsky Performance Scale (100-0, optimum-death), and a Visual Analogue Scale (VAS) (0: no pain; 10: worst pain) were used to measure the level of pain. Data were collected at baseline (T0), on the 7th day (T1), and on the 14th day (T2) of TTS-F application in order to determine changes in correlation to TTS-F dose. Patients' status improved according to the Zung SDS questionnaire (P < .0005) and with each of its subscales (P < .05). A similar improvement was observed according to the Spielberger STAI questionnaire (P = .002). Moreover, VAS measures demonstrated that patients achieved significant pain relief (P < .0005), while patients' performance status did not alter significantly over the study period. Furthermore, the Zung SDS showed a sta...Continue Reading

References

Feb 1, 1992·Journal of Pain and Symptom Management·M J Massie, J C Holland
Apr 1, 1988·Acta Anaesthesiologica Scandinavica·A Vainio, I Tigerstedt
Apr 1, 1983·Neuropharmacology·J W VilligerK M Taylor
Feb 1, 1995·Journal of Pain and Symptom Management·M L VachonI Higginson
Jan 1, 1995·Psychotherapy and Psychosomatics·G VelikovaP G Kirby
Apr 22, 1995·BMJ : British Medical Journal·F LarueC S Cleeland
Apr 1, 1994·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C A MeyersD Przepiorka
Mar 1, 1994·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·W Korte, R Morant
Oct 1, 1996·Journal of Pain and Symptom Management·J E HammackA W Miser
Jul 1, 1997·Palliative Medicine·P Strang
Apr 29, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R PayneR Mahmoud
Jun 18, 1998·Primary Care·T L Schwenk
Sep 16, 1998·Journal of Pain and Symptom Management·P A SloanH Hays
Feb 25, 2003·Palliative Medicine·Mari Lloyd-WilliamsJason Ward
Jan 1, 1965·Archives of General Psychiatry·W W ZUNG

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