Investigating the Efficacy of Triple Artemisinin-Based Combination Therapies for Treating Plasmodium falciparum Malaria Patients Using Mathematical Modeling.

Antimicrobial Agents and Chemotherapy
Saber DiniJulie A Simpson

Abstract

The first line treatment for uncomplicated falciparum malaria is artemisinin-based combination therapy (ACT), which consists of an artemisinin derivative coadministered with a longer-acting partner drug. However, the spread of Plasmodium falciparum resistant to both artemisinin and its partner drugs poses a major global threat to malaria control activities. Novel strategies are needed to retard and reverse the spread of these resistant parasites. One such strategy is triple artemisinin-based combination therapy (TACT). We developed a mechanistic within-host mathematical model to investigate the efficacy of a TACT (dihydroartemisinin-piperaquine-mefloquine [DHA-PPQ-MQ]) for use in South-East Asia, where DHA and PPQ resistance are now increasingly prevalent. Comprehensive model simulations were used to explore the degree to which the underlying resistance influences the parasitological outcomes. The effect of MQ dosing on the efficacy of TACT was quantified at various degrees of DHA and PPQ resistance. To incorporate interactions between drugs, a novel model is presented for the combined effect of DHA-PPQ-MQ, which illustrates how the interactions can influence treatment efficacy. When combined with a standard regimen of DHA and ...Continue Reading

References

Jul 1, 1990·Journal of Pharmacological Methods·J L Plummer, T G Short
Jun 7, 1985·Journal of Theoretical Biology·M C Berenbaum
Jan 30, 1999·Antimicrobial Agents and Chemotherapy·R PriceN J White
Dec 1, 1999·Clinical Pharmacology and Therapeutics·J A SimpsonN J White
Dec 5, 2000·Journal of Biopharmaceutical Statistics·C Gennings
Aug 15, 2002·Proceedings of the National Academy of Sciences of the United States of America·Rachanee UdomsangpetchNicholas J White
Mar 1, 1964·The Journal of Pharmacy and Pharmacology·E J ARIUENS, A M SIMONIS
Jun 5, 2004·Proceedings of the National Academy of Sciences of the United States of America·Philip G McQueen, F Ellis McKenzie
Dec 22, 2004·Drugs·Timothy M E DavisKenneth F Ilett
May 4, 2006·The Journal of Pharmacology and Experimental Therapeutics·Ronald J Tallarida
Jul 28, 2006·Antimicrobial Agents and Chemotherapy·Timothy M E DavisP Hugh R Barrett
Mar 28, 2008·Proceedings. Biological Sciences·Rustom AntiaJacobus C de Roode
Jul 31, 2009·The New England Journal of Medicine·Arjen M DondorpNicholas J White
Mar 26, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Paul M O'NeillStephen A Ward
Dec 22, 2010·Proceedings of the National Academy of Sciences of the United States of America·Sompob SaralambaLisa J White
May 4, 2011·Antimicrobial Agents and Chemotherapy·Katherine Winter, Ian M Hastings
Oct 10, 2012·ACS Chemical Biology·Jill M CombrinckTimothy J Egan
Feb 23, 2013·Proceedings of the National Academy of Sciences of the United States of America·Nectarios KlonisLeann Tilley
Sep 21, 2013·Annual Review of Pharmacology and Toxicology·David Horn, Manoj T Duraisingh
Jul 31, 2014·The New England Journal of Medicine·Elizabeth A AshleyUNKNOWN Tracking Resistance to Artemisinin Collaboration (TRAC)
Feb 24, 2016·Antimicrobial Agents and Chemotherapy·Eva Maria HodelIan M Hastings
Jun 24, 2016·Microbiology Spectrum·Rick M Fairhurst, Arjen M Dondorp
Mar 16, 2017·Proceedings of the National Academy of Sciences of the United States of America·Ricardo AtaideFreya J I Fowkes
Mar 23, 2017·Emerging Infectious Diseases·Bui Quang PhucNguyen Quang Thieu
Oct 11, 2017·Antimicrobial Agents and Chemotherapy·Pengxing CaoJames M McCaw

❮ Previous
Next ❯

Citations

Oct 24, 2019·The American Journal of Tropical Medicine and Hygiene·Matthew R Hassett, Paul D Roepe
Jan 8, 2020·Antimicrobial Agents and Chemotherapy·Chu Xuan AnhMichael D Edstein
Sep 10, 2020·Annual Review of Microbiology·Kathryn J WichtDavid A Fidock
Feb 6, 2019·Tropical Medicine and Infectious Disease·Christian Nsanzabana
Feb 29, 2020·Journal of Clinical Pharmacology·Juntra Karbwang, Kesara Na-Bangchang
Oct 30, 2020·The Journal of Infectious Diseases·Maria RebeloDavid S Khoury
Oct 17, 2020·Trends in Parasitology·Rob W van der PluijmArjen M Dondorp
Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Richard M BeteckSetshaba D Khanye
Feb 3, 2021·Antimicrobial Agents and Chemotherapy·Lydia BurgertMelissa A Penny
Jun 29, 2021·The Journal of Antimicrobial Chemotherapy·Saber DiniJulie A Simpson
Jul 10, 2021·Journal of Medicinal Chemistry·Lovepreet Singh, Kamaljit Singh
Aug 6, 2021·Expert Review of Anti-infective Therapy·Charlotte RasmussenPascal Ringwald
Aug 27, 2021·The Journal of Experimental Medicine·Huynh Dinh ChienFrancesco M Turrini

❮ Previous
Next ❯

Clinical Trials Mentioned

NCT02453308

Software Mentioned

appTACT

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

CRISPR Screens in Drug Resistance

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on the application of CRISPR-Cas system in high-throughput genome-wide screens to identify genes that may confer drug resistance.

Related Papers

Travel Medicine and Infectious Disease
Borimas Hanboonkunupakarn, Nicholas J White
Nature Reviews. Microbiology
Kasturi HaldarInnocent Safeukui
The Cochrane Database of Systematic Reviews
Hasifa BukirwaPrathap Tharyan
© 2022 Meta ULC. All rights reserved