Investigating the empirical support for therapeutic targets proposed by the temporal experience of pleasure model in schizophrenia: A systematic review

Schizophrenia Research
Clementine J EdwardsTil Wykes

Abstract

Anhedonia and amotivation are substantial predictors of poor functional outcomes in people with schizophrenia and often present a formidable barrier to returning to work or building relationships. The Temporal Experience of Pleasure Model proposes constructs which should be considered therapeutic targets for these symptoms in schizophrenia e.g. anticipatory pleasure, memory, executive functions, motivation and behaviours related to the activity. Recent reviews have highlighted the need for a clear evidence base to drive the development of targeted interventions. To review systematically the empirical evidence for each TEP model component and propose evidence-based therapeutic targets for anhedonia and amotivation in schizophrenia. Following PRISMA guidelines, PubMed and PsycInfo were searched using the terms "schizophrenia" and "anhedonia". Studies were included if they measured anhedonia and participants had a diagnosis of schizophrenia. The methodology, measures and main findings from each study were extracted and critically summarised for each TEP model construct. 80 independent studies were reviewed and executive functions, emotional memory and the translation of motivation into actions are highlighted as key deficits with ...Continue Reading

References

Jun 1, 1978·Archives of General Psychiatry·R L SpitzerE Robins
Aug 1, 1976·Journal of Abnormal Psychology·L J ChapmanM L Raulin
Jan 1, 1987·Schizophrenia Bulletin·S R KayL A Opler
Jan 1, 1987·Neuropsychobiology·D KemaliA Mucci
Jul 1, 1982·Archives of General Psychiatry·N C Andreasen
Jul 1, 1995·The British Journal of Psychiatry : the Journal of Mental Science·R P SnaithP Trigwell
Jun 1, 1995·Biological Psychiatry·M A HammerW G Iacono
Jan 1, 1995·European Archives of Psychiatry and Clinical Neuroscience·R SchlenkerG Hopmann
Feb 28, 1997·Schizophrenia Research·P W WoodruffA S David
Aug 5, 1998·Schizophrenia Research·S W QuirkD M Sloan
Jul 31, 2001·JAMA : the Journal of the American Medical Association·B Crespo-FacorroR D Hichwa
Nov 25, 2003·Schizophrenia Research·William P Horan, Jack J Blanchard
Feb 27, 2004·Schizophrenia Research·Edward I GelberRaquel E Gur
Sep 6, 2005·NeuroImage·Georg JuckelAndreas Heinz
Sep 27, 2005·Schizophrenia Research·Mikisha L Doop, Sohee Park
Feb 17, 2006·Schizophrenia Bulletin·Brian KirkpatrickStephen R Marder
Mar 4, 2006·The American Journal of Psychiatry·Douglas TurkingtonPeter J Weiden
Jul 27, 2006·Journal of Abnormal Psychology·William P HoranKeith H Nuechterlein
Aug 4, 2006·Psychiatry Research·Eun LeeHong Shick Lee
Jan 24, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·Acioly L T LacerdaMatcheri S Keshavan
Feb 28, 2007·Journal of Abnormal Psychology·Jennifer A Burbridge, Deanna M Barch
Feb 28, 2007·Journal of Abnormal Psychology·Ellen S HerbenerJohn A Sweeney
May 2, 2007·The British Journal of Psychiatry : the Journal of Mental Science·Til WykesRenee Romeo
May 11, 2007·Schizophrenia Research·David E GardMichael F Green
May 23, 2007·Journal of Abnormal Psychology·Erin A Heerey, James M Gold
Aug 9, 2007·Molecular Psychiatry·G K MurrayP C Fletcher
Aug 11, 2007·Schizophrenia Research·Ellen S HerbenerJohn A Sweeney
Aug 19, 2007·Journal of the International Neuropsychological Society : JINS·Gildas BrébionLyn S Pilowsky
Dec 22, 2007·Psychopharmacology·Florian SchlagenhaufAndreas Heinz
Jan 24, 2008·Journal of Psychiatric Practice·Shanaya RathodDouglas Turkington
Apr 22, 2008·Psychiatry Research·Howard BerenbaumJose J Gomez
Jul 2, 2008·Schizophrenia Bulletin·James M GoldErin A Heerey
Jul 18, 2008·Schizophrenia Bulletin·Ellen S Herbener
Oct 10, 2008·Schizophrenia Bulletin·Gabriel S DichterAysenil Belger
Dec 5, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·James A WaltzElliot A Stein

❮ Previous
Next ❯

Citations

May 23, 2020·Psychological Medicine·Karlijn S F M HermansUlrich Reininghaus
Jan 20, 2021·Psychiatry Research·Laina E RosebrockDaniel Freeman
Jul 15, 2021·Schizophrenia Research. Cognition·Daniel KrzyzanowskiGary Remington
Dec 11, 2021·Schizophrenia Bulletin·Daniel J KrzyzanowskiVina Goghari

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here

Brain Circuits in Emotional Learning

The neuronal circuits within the cortico-limbic brain regions form networks that mediate emotional behavior. Areas specific to emotional learning include the basal amygdala and sublenticular extended amygdala region along with a supplemental motor area. Discover the latest research on brain circuits in emotional learning here.