Investigating the field-dependence of the Davis model: Calibrated fMRI at 1.5, 3 and 7T

NeuroImage
Hannah V HareDaniel P Bulte

Abstract

Gas calibrated fMRI in its most common form uses hypercapnia in conjunction with the Davis model to quantify relative changes in the cerebral rate of oxygen consumption (CMRO2) in response to a functional stimulus. It is most commonly carried out at 3T but, as 7T research scanners are becoming more widespread and the majority of clinical scanners are still 1.5T systems, it is important to investigate whether the model used remains accurate across this range of field strengths. Ten subjects were scanned at 1.5, 3 and 7T whilst performing a bilateral finger-tapping task as part of a calibrated fMRI protocol, and the results were compared to a detailed signal model. Simulations predicted an increase in value and variation in the calibration parameter M with field strength. Two methods of defining experimental regions of interest (ROIs) were investigated, based on (a) BOLD signal and (b) BOLD responses within grey matter only. M values from the latter ROI were in closer agreement with theoretical predictions; however, reassuringly, ROI choice had less impact on CMRO2 than on M estimates. Relative changes in CMRO2 during motor tasks at 3 and 7T were in good agreement but were over-estimated at 1.5T as a result of the lower signal to...Continue Reading

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Citations

Feb 3, 2016·NMR in Biomedicine·Kawin SetsompopJonathan R Polimeni
Jul 2, 2016·NeuroImage·Maria GuidiHarald E Möller
Jan 21, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Krishna A DaniKeith W Muir
Nov 17, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Samira M KazanNikolaus Weiskopf
Aug 29, 2020·Diagnostics·Yurii ShepelytskyiMitchell S Albert

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Software Mentioned

QUIPSS
FMRIB Software Library ( FSL )
MATLAB
fMRI Expert Analysis Tool ( FEAT )
FEAT

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