Investigating the generalisation of an atlas-based synthetic-CT algorithm to another centre and MR scanner for prostate MR-only radiotherapy

Physics in Medicine and Biology
Jonathan J WyattHazel M McCallum

Abstract

There is increasing interest in MR-only radiotherapy planning since it provides superb soft-tissue contrast without the registration uncertainties inherent in a CT-MR registration. However, MR images cannot readily provide the electron density information necessary for radiotherapy dose calculation. An algorithm which generates synthetic CTs for dose calculations from MR images of the prostate using an atlas of 3 T MR images has been previously reported by two of the authors. This paper aimed to evaluate this algorithm using MR data acquired at a different field strength and a different centre to the algorithm atlas. Twenty-one prostate patients received planning 1.5 T MR and CT scans with routine immobilisation devices on a flat-top couch set-up using external lasers. The MR receive coils were supported by a coil bridge. Synthetic CTs were generated from the planning MR images with ([Formula: see text]) and without (sCT) a one voxel body contour expansion included in the algorithm. This was to test whether this expansion was required for 1.5 T images. Both synthetic CTs were rigidly registered to the planning CT (pCT). A 6 MV volumetric modulated arc therapy plan was created on the pCT and recalculated on the sCT and [Formula:...Continue Reading

References

Feb 16, 1999·International Journal of Radiation Oncology, Biology, Physics·C RaschJ V Lebesque
Oct 27, 2004·NeuroImage·Bruce FischlAnders M Dale
Apr 6, 2006·Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society·Jayaram K UdupaJames Woodburn
Sep 19, 2006·The British Journal of Radiology·V S Khoo, D L Joon
Apr 13, 2007·IEEE Transactions on Medical Imaging·Xiao Han, Bruce Fischl
Sep 26, 2007·Magnetic Resonance Imaging Clinics of North America·Brian J SoherElmar M Merkle
Dec 29, 2007·European Journal of Radiology·Olaf DietrichStefan O Schoenberg
May 6, 2010·NeuroImage·Corinna M BauerUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Feb 23, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Jonathan LambertOlivier Salvado
Jul 10, 2012·Magnetic Resonance Imaging·Andriy FedorovRon Kikinis
Oct 9, 2012·Medical Physics·Csaba PinterGabor Fichtinger
Jun 17, 2014·Seminars in Radiation Oncology·Gary P Liney, Marinus A Moerland
Jan 24, 2015·AJNR. American Journal of Neuroradiology·N ChowUNKNOWN Alzheimer's Disease Neuroimaging Initiative
May 7, 2015·Computational and Mathematical Methods in Medicine·Ivana DespotovićWilfried Philips
May 12, 2016·Journal of Applied Clinical Medical Physics·Shupeng ChenDi Yan
Jan 12, 2017·Physics in Medicine and Biology·Matteo MasperoCornelis A T van den Berg
May 14, 2017·Injury·Tristan E McMillan, Alan J Johnstone
Oct 13, 2017·Physical Chemistry Chemical Physics : PCCP·Joshua E S J ReidAdam J Walker

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Citations

Feb 3, 2018·Physics in Medicine and Biology·Amir M OwrangiCarri K Glide-Hurst
Aug 19, 2021·Medical Physics·Maria Francesca SpadeaJoao Seco

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