Investigating the impact of chronic atrazine exposure on sexual development in zebrafish.

Birth Defects Research. Part B, Developmental and Reproductive Toxicology
Margaret M CorviRobert L Tanguay

Abstract

Atrazine (ATZ) is a selective triazine herbicide used primarily for preemergent weed control in corn, sorghum, and sugar cane production. It is one of the most widely used herbicides in North America. Some research published over the last decade suggests that chronic exposure to environmentally relevant ATZ concentrations can adversely impact gonadal development and/or sexual differentiation in amphibians and fish, while other studies report no effect, or moderate effects. As a result, contrasting conclusions have been published regarding the potential effects of the herbicide ATZ on aquatic species. Two near-identical 4-month studies in 2009 (Study I) and 2010 (Study II) were performed investigating the potential for chronic ATZ exposure to affect zebrafish (Danio rerio) sexual development and differentiation. Zebrafish were chronically exposed to 0, 0.1, 1, 10 μM ATZ or 1 nM 17β-estradiol (E2). Fish were histologically examined to assign gender and to evaluate potential impacts of E2 or ATZ on gonadal development. Exposure to E2 consistently resulted in a significantly higher proportion of female fish to normal male fish when compared to unexposed fish (both studies). In both studies, ATZ exposure did not significantly influe...Continue Reading

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Citations

Nov 7, 2014·Critical Reviews in Toxicology·Glen J Van Der KraakKeith R Solomon
Jul 15, 2016·Toxicological Sciences : an Official Journal of the Society of Toxicology·Sara E WirbiskyJennifer L Freeman
Nov 28, 2013·Journal of Toxicology and Environmental Health. Part a·Katherine FlynnFrancois Gagné
Feb 16, 2017·Environmental Toxicology and Chemistry·Alan J HosmerRichard A Brain
Aug 17, 2019·Journal of Fish Diseases·Carolyn T ChangChristopher M Whipps
May 21, 2019·Environmental Pollution·Jacob A ClearyRamji K Bhandari

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