Investigating the link between epithelial-mesenchymal transition and the cancer stem cell phenotype: A mathematical approach

Journal of Theoretical Biology
C Turner, M Kohandel

Abstract

Under the cancer stem cell (CSC) hypothesis, sustained metastatic growth requires the dissemination of a CSC from the primary tumour followed by its re-establishment in a secondary site. The epithelial-mesenchymal transition (EMT), a differentiation process crucial to normal development, has been implicated in conferring metastatic ability on carcinomas. Balancing these two concepts has led researchers to investigate a possible link between EMT and the CSC phenotype-indeed, recent evidence indicates that, following induction of EMT in human breast cancer and related cell lines, stem cell activity increased, as judged by the presence of cells displaying the CD44(high)/CD24(low) phenotype and an increase in the ability of cells to form mammospheres. We mathematically investigate the nature of this increase in stem cell activity. A stochastic model is used when small number of cells are under consideration, namely in simulating the mammosphere assay, while a related continuous model is used to probe the dynamics of larger cell populations. Two scenarios of EMT-mediated CSC enrichment are considered. In the first, differentiated cells re-acquire a CSC phenotype-this model implicates fully mature cells as key subjects of de-differen...Continue Reading

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Citations

May 9, 2014·PloS One·Andrew DhawanSivabal Sivaloganathan
Sep 5, 2014·Journal of the Royal Society, Interface·Kerri-Ann Norton, Aleksander S Popel
Oct 23, 2013·Molecular Aspects of Medicine·George F MurphyMarkus H Frank
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May 23, 2012·Seminars in Cancer Biology·C Turner, M Kohandel
May 11, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Chih-Jung YaoTung-Yuan Lai
Nov 12, 2016·Mathematical Biosciences·Seyed Ali Madani TonekaboniMohammad Kohandel
Mar 30, 2011·Laboratory Investigation; a Journal of Technical Methods and Pathology·Sasha D Girouard, George F Murphy
Mar 26, 2020·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Marilisa CortesiEmanuele Giordano
Aug 14, 2020·Journal of Clinical Medicine·Maria Chiara LionettiCaterina A M La Porta
Sep 1, 2015·Oncotarget·Mohit Kumar JollyHerbert Levine

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