Investigating the order parameters of saturated lipid molecules under various curvature conditions on spherical supported lipid bilayers

The Journal of Physical Chemistry. B
Lauren E MarbellaMegan M Spence

Abstract

The conformations and motions of lipid molecules under different membrane curvatures have important implications for transmembrane protein function, binding events, and overall membrane organization. This work reports on the local order parameters of saturated lipid molecules, as measured by (13)C NMR relaxation, under several curvature conditions to probe structural changes as a function of lipid bilayer curvature. Different curvature conditions are created by depositing phosphatidylcholine membranes on spherical beads of various diameters. The findings reveal that the order parameters are not a continuous function of the membrane curvature. While small (30 nm) and large (110 nm) diameter bilayers exhibit similar order parameters, bilayers with curvatures of 60-80 nm diameter show a consistently increased order parameter along the entire lipid molecule, indicating a higher packing density and lateral tension. Order parameters for curvatures between 60 and 80 nm also show molecular evidence for interdigitation.

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Citations

Jan 26, 2016·Biochimica Et Biophysica Acta·O H Samuli Ollila, Georg Pabst
Feb 22, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Florence BlachonJean-Paul Rieu
May 6, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Oumaima Et-ThakafyFanny Guyomarc'h

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