Investigating the Potential for Bias When Using a Widely Accepted Medication Adherence Measure to Predict Mortality

Pharmacotherapy
Ralph C WardMulugeta Gebregziabher

Abstract

Summary measures of medication adherence, such as the proportion of days covered (PDC), are often used to analyze the association between medication adherence and various health outcomes. We hypothesized that PDC and similar measures may lead to biased results in some situations when used to estimate the association between adherence and the outcome event (e.g., mortality). Thus, the objective was to determine the conditions under which PDC and similar measures might produce biased estimates of the association between adherence and mortality and to review methods to avoid such bias. Simulation study and analysis of data from a large retrospective cohort study. We conducted a comprehensive simulation to compare how adherence estimates varied-using prescription-based (end point was final date that medications were on hand or date of death) and interval-based (end point based on fixed calendar interval or date of death) PDC denominators-when deaths occurred either during or after the adherence exposure period. We then made similar comparisons using data from a retrospective study that included comprehensive measures of medication refill activity and clinical outcomes of 207,841 patients with diabetes mellitus who were prescribed o...Continue Reading

References

Feb 7, 1998·Medical Care·A ElixhauserR M Coffey
May 24, 2005·Medical Care·Michael C SokolRobert S Epstein
Aug 5, 2005·The New England Journal of Medicine·Lars Osterberg, Terrence Blaschke
Sep 27, 2006·Archives of Internal Medicine·P Michael HoDavid J Magid
Jan 11, 2007·JAMA : the Journal of the American Medical Association·Jeppe N RasmussenDavid A Alter
Jan 8, 2009·The Annals of Pharmacotherapy·Bradley C MartinBetsy Lynn Sleath
Mar 6, 2009·The Annals of Pharmacotherapy·Richard A HansenMichael D Murray
Sep 28, 2015·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Piia K RannanheimoMaarit Jaana Korhonen
Apr 17, 2016·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Miklos Z MolnarCsaba P Kovesdy
May 3, 2016·The Journal of Clinical Psychiatry·Amir KrivoyGal Shoval
Nov 3, 2016·Pharmacoepidemiology and Drug Safety·Valeria BelleudiUNKNOWN OUTPUL Study Group
Aug 20, 2016·Journal of the American College of Cardiology·Sameer BansilalValentin Fuster

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