Investigating the role of cholesterol in the formation of non-ionic surfactant based bilayer vesicles: thermal analysis and molecular dynamics

International Journal of Pharmaceutics
Jitinder S WilkhuYvonne Perrie

Abstract

The aim of this research was to investigate the molecular interactions occurring in the formulation of non-ionic surfactant based vesicles composed monopalmitoyl glycerol (MPG), cholesterol (Chol) and dicetyl phosphate (DCP). In the formulation of these vesicles, the thermodynamic attributes and surfactant interactions based on molecular dynamics, Langmuir monolayer studies, differential scanning calorimetry (DSC), hot stage microscopy and thermogravimetric analysis (TGA) were investigated. Initially the melting points of the components individually, and combined at a 5:4:1 MPG:Chol:DCP weight ratio, were investigated; the results show that lower (90 °C) than previously reported (120-140 °C) temperatures could be adopted to produce molten surfactants for the production of niosomes. This was advantageous for surfactant stability; whilst TGA studies show that the individual components were stable to above 200 °C, the 5:4:1 MPG:Chol:DCP mixture show ∼2% surfactant degradation at 140 °C, compared to 0.01% was measured at 90 °C. Niosomes formed at this lower temperature offered comparable characteristics to vesicles prepared using higher temperatures commonly reported in literature. In the formation of niosome vesicles, cholesterol ...Continue Reading

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Citations

Oct 14, 2014·Journal of Liposome Research·Nahid KamalAhmed S Zidan
Dec 3, 2014·International Journal of Pharmaceutics·Yongtai ZhangNianping Feng
Sep 12, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Kenji AramakiKyuhei Kitao
Sep 1, 2016·International Journal of Pharmaceutics·Chenjun ShiShirui Mao
Apr 16, 2019·Journal of Microencapsulation·Boontida MorakulVaraporn Buraphacheep Junyaprasert
Jan 16, 2020·Therapeutic Delivery·Swati MittalAnkit Kumar
Nov 6, 2018·Journal of Pharmaceutical Sciences·Dallas B WarrenColin W Pouton

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