Investigating the Stability of Fine-Grain Digit Somatotopy in Individual Human Participants

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
James KolasinskiHeidi Johansen-Berg

Abstract

Studies of human primary somatosensory cortex (S1) have placed a strong emphasis on the cortical representation of the hand and the propensity for plasticity therein. Despite many reports of group differences and experience-dependent changes in cortical digit somatotopy, relatively little work has considered the variability of these maps across individuals and to what extent this detailed functional architecture is dynamic over time. With the advent of 7 T fMRI, it is increasingly feasible to map such detailed organization noninvasively in individual human participants. Here, we extend the ability of ultra-high-field imaging beyond a technological proof of principle to investigate the intersubject variability of digit somatotopy across participants and the stability of this organization across a range of intervals. Using a well validated phase-encoding paradigm and an active task, we demonstrate the presence of highly reproducible maps of individual digits in S1, sharply contrasted by a striking degree of intersubject variability in the shape, extent, and relative position of individual digit representations. Our results demonstrate the presence of very stable fine-grain somatotopy of the digits in human S1 and raise the issue ...Continue Reading

Citations

Aug 24, 2016·ELife·Sanne KikkertTamar R Makin
Dec 30, 2017·The Journal of Physiology·Franck-Emmanuel RouxJean-Baptiste Durand
Dec 31, 2016·ELife·James KolasinskiHeidi Johansen-Berg
Feb 2, 2020·Brain Structure & Function·Christian R LeeDavid J Margolis
Oct 4, 2018·Frontiers in Behavioral Neuroscience·Francesca BenuzziPaolo Frigio Nichelli
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Jul 1, 2018·NeuroImage·Eleanor L BarrattMatthew J Brookes

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