Investigating the synchronization of hippocampal neural network in response to acute nicotine exposure.

Journal of Neuroengineering and Rehabilitation
David AkkurtMetin Akay

Abstract

Previous studies suggested that gamma oscillations in the brain are associated with higher order cognitive function including selective visual attention, motor task planning, sensory perception, working memory and dreaming REM sleep. These oscillations are mainly observed in cortical regions and also occur in neocortical and subcortical areas and the hippocampus. In this paper, we investigate the influence of acute exposure to nicotine on the complexity of hippocampal gamma oscillations.Using the approximate entropy method, the influence of acute nicotine exposure on the hippocampal gamma oscillations was investigated. The hippocampal gamma oscillations have been generated in response to the 100 Hz stimulus and isolated using the visual inspection and spectral analysis method. Our central hypothesis is that acute exposure to nicotine significantly reduces the complexity of hippocampal gamma oscillations. We used brain-slice recordings and the approximate entropy method to test this hypothesis. The approximate entropy (complexity) values of the hippocampal gamma oscillations are estimated from the 14 hippocampal slices. Our results show that it takes at least 100 msec to see any hippocampal activities in response to the 100 Hz s...Continue Reading

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Citations

Jan 1, 2021·Journal of Personalized Medicine·Jessica U RamlakhanMera S Barr

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