Investigating transcription reinitiation through in vitro approaches

Transcription
Giorgio DieciMaria Cristina Bosio

Abstract

By influencing the number of RNA molecules repeatedly synthesized from the same gene, the control of transcription reinitiation has the potential to shape the transcriptome. Transcription reinitiation mechanisms have been mainly addressed in vitro, through approaches based on both crude and reconstituted systems. These studies support the notion that transcription reinitiation and its regulation rely on dedicated networks of molecular interactions within transcription machineries. At the same time, comparison with in vivo transcription rates suggests that additional mechanisms, factors and conditions must exist in the nucleus, whose biochemical elucidation is a fascinating challenge for future in vitro transcription studies.

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Citations

May 23, 2014·Journal of the Royal Society, Interface·Bo LiuLuonan Chen
Dec 20, 2018·Royal Society Open Science·Mahendra Kumar Prajapat, Andre S Ribeiro
Aug 17, 2021·Frontiers in Molecular Biosciences·Elisabeth LataMartin Teichmann
Nov 5, 2021·Nature Communications·Zhong ChenQianben Wang

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