Investigation into High Barmah Forest Virus Disease Case Numbers Reported in the Northern Territory, Australia in 2012-2013

Vector Borne and Zoonotic Diseases
Nina KuruczDanielle Stokeld

Abstract

Between October 2012 and October 2013, unprecedented high numbers of Barmah Forest virus (BFV) disease cases were reported in the Northern Territory (NT). An investigation was launched by the NT Department of Health in cooperation with the Department of Primary Industry and Fisheries and the Department of Land Resource Management to investigate possible causes for this phenomenon. The investigation included virus isolations from mosquitoes collected in Darwin urban areas, BFV antibody testing in peri-urban small mammals and a human BFV disease case series investigation of recent cases. No BFV was isolated from the 4641 mosquitoes tested, none of the mammals tested positive for BFV antibodies, and the high BFV disease case numbers did not correlate with the relatively low mosquito vector numbers trapped in 2012-2013. It was estimated that up to 89% of the 79 human cases investigated did not have an acute arboviral illness and therefore had tested falsely positive. An Alere PanBio BFV immunoglobulin M enzyme-linked immunosorbent assay test kit is generally used to test for BFV, with the BFV disease case definition based on immunoglobulin M positives only. Other jurisdictions in Australia also reported high numbers of BFV disease ...Continue Reading

References

Jun 1, 1987·The Medical Journal of Australia·R A HawkesL G Ramsay
Jan 1, 1984·Australian Journal of Biological Sciences·H A StandfastC Filippich
Mar 20, 1995·The Medical Journal of Australia·M D LindsayJ S Mackenzie
Sep 12, 1998·The Medical Journal of Australia·J P FlexmanA L Cunningham
Apr 8, 2004·The Australasian Journal of Dermatology·Amanda Dore, John Auld

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Citations

Sep 11, 2020·Microorganisms·Rana Abdelnabi, Leen Delang
Nov 9, 2020·The Lancet Infectious Diseases·Ali ZaidSuresh Mahalingam

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA

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