PMID: 628Nov 21, 1975

Investigation into some imidazoline compounds, with respect to peripheral alpha-adrenoceptor stimulation and depression of cardiovascular centers

Naunyn-Schmiedeberg's Archives of Pharmacology
W Kobinger, L Pichler

Abstract

Peripheral alpha-adrenoceptor stimulation was tested by means of hypertensive effects of the drugs following i.v. injection in spinal rats. Naphazoline (NP), oxymetazoline (OM), St 91-2-(2,6-diethylphenylimino)-2-imidazolidine--and St 1697--2-(2-ethyl, 6-methylphenylimino)-2-imidazolidine--were 3 to 5 times more potent in tthis respect thatn clonidine (CLON) whereas St 363--2-(2,4-dichlorophenylimino)-2-imidazolidine--and xylazine (XY) exerted only approx. 1/20 the effect of that of clonidine. Sympathoinhibitory activity after i.v. injection was tested by the bradycardiac effect in vagotomized rats; St 1697, St 363 and XY were active, approx. 1/10-1/30 of CLON, whereas NP, OM and St 91 were inactive. However, following intracisternal (i.ci.) injection of cardiovascular depression, typical for clonidine: (1) in dogs with blocked beta-adrenoceptors, the drugs facilitated the vagally meditated cardiodepressor reflex in response to baroreceptor stimulation by i.v. injection of angiotensin; (2) in dogs treated with atropine and in (3) vagotomized cats (only NP, OM and St 363) a long lasting decrease in heart rate was observed. Some of the experiments were complicated by increases in blood pressure, due to the "leakage" of small amou...Continue Reading

References

Jan 1, 1975·Naunyn-Schmiedeberg's Archives of Pharmacology·W Kobinger, L Pichler
Sep 1, 1974·Life Sciences·H S BoudierJ van Rossum
Sep 1, 1971·European Journal of Pharmacology·W Kobinger, A Walland
Jan 1, 1971·European Journal of Pharmacology·A M AutretN Pétillot
Aug 1, 1972·European Journal of Pharmacology·W Kobinger, A Walland
Aug 1, 1972·European Journal of Pharmacology·W Kobinger, A Walland

Citations

Sep 1, 1992·Medicinal Research Reviews·A Barber, R Gottschlich
Jan 1, 1983·Psychopharmacology·M J DeniardF V DeFeudis
Oct 1, 1977·European Journal of Pharmacology·P B Timmermans, P A Van Zwieten
Jun 15, 1977·European Journal of Pharmacology·A ScriabineN R Bohidar
Aug 15, 1977·European Journal of Pharmacology·J M Cedarbaum, G K Aghajanian
Dec 1, 1978·European Journal of Pharmacology·P L McLennan, G A Bentley
Sep 24, 1981·European Journal of Pharmacology·M C Koss
May 22, 1981·European Journal of Pharmacology·A De JongeP A Van Zwieten
Feb 9, 1988·European Journal of Pharmacology·M Nakamura, S H Ferreira
Jan 1, 1979·Comparative Biochemistry and Physiology. C: Comparative Pharmacology·P Johansson
Sep 1, 1977·The Journal of Pharmacy and Pharmacology·J Vetulani, B Bednarczyk
Aug 1, 1981·Naunyn-Schmiedeberg's Archives of Pharmacology·A De JongeP A Van Zwieten
Jan 1, 1978·Clinical and Experimental Hypertension : CHE·W Kobinger, L Pichler
Oct 27, 2011·Pharmazie in unserer Zeit·Jens Schmitz, Ulrike Holzgrabe
Feb 24, 1988·The American Journal of Cardiology·W J LouisE L Conway
Feb 24, 1988·The American Journal of Cardiology·E Koenig-BerardC Labrid
Apr 1, 1988·Pharmacological Research Communications·A VeeranjaneyuluK C Dave
Apr 1, 1982·The Journal of Pharmacy and Pharmacology·A Veeranjaneyulu, S C Verma
Feb 1, 1986·Naunyn-Schmiedeberg's Archives of Pharmacology·W Kobinger
Jan 1, 1981·Journal of Clinical Pharmacology·B FalknerD T Lowenthal

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Adrenergic alpha-Agonists
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