Investigation into the cardioregulatory properties of the alpha 1-adrenoceptor blocker indoramin

British Journal of Pharmacology
V PierceJ F Waterfall


The cardioregulatory properties of the alpha 1-adrenoceptor blocker indoramin have been compared with those of prazosin in the anaesthetized rat. The effects of autonomic blockade on heart rate responses evoked by these two agents and their effects on blood pressure and heart rate after peripheral or central administration have been compared. Cumulative administration of indoramin (0.8-25.6 mg kg-1 i.v.) evoked significant decreases in arterial blood pressure and a concomitant bradycardia. Pithing or autonomic blockade, by pretreatment with a combination of practolol and bilateral vagotomy, prevented the bradycardia evoked by indoramin (0.8-3.2 mg kg-1 i.v.). Atropine sulphate pretreatment abolished the bradycardia until a cumulative dose of 25.6 mg kg-1(i.v.) of indoramin had been reached. Bilateral vagotomy, intravenous administration of atropine methylnitrate or practolol pretreatment attenuated the bradycardia. Prazosin (0.02-0.64 mg kg-1 i.v.) evoked a fall in arterial blood pressure of similar magnitude to that observed following indoramin. A bradycardia was evoked only at a relatively high dose (0.64 mg kg-1 i.v.). Intracisternal injection of indoramin or prazosin evoked bradycardia and hypotension at a dose which had no...Continue Reading


May 1, 1975·European Journal of Pharmacology·T Baum, A T Shropshire
Jan 1, 1974·Current Medical Research and Opinion·R CarballoJ Suarez
Sep 1, 1971·The Journal of Pharmacy and Pharmacology·B J AlpsA B Wilson
Nov 27, 1984·European Journal of Pharmacology·A G Ramage
Feb 1, 1981·Journal of the Autonomic Nervous System·R B McCall, S J Humphrey
Apr 1, 1981·The Journal of Pharmacy and Pharmacology·D R AlgateJ F Waterfall
Oct 1, 1980·Canadian Journal of Physiology and Pharmacology·B G Benfey
Jul 1, 1981·British Journal of Pharmacology·N A Flavahan, J C McGrath
Jan 1, 1983·British Journal of Clinical Pharmacology·D P NichollsR G Shanks
Jan 1, 1982·Annual Review of Pharmacology and Toxicology·H E Brezenoff, R Giuliano
Jul 1, 1965·International Journal of Neuropharmacology·A HERZH KURZ

Related Concepts

Diastolic Blood Pressure
Pulse Rate
Intravenous Injections
Injections, Intraventricular
August Rats
Sympathetic Nervous System

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.


Bradyarrhythmias are slow heart rates. Symptoms may include syncope, dizziness, fatigure, shortness of breath, and chest pains. Find the latest research on bradyarrhythmias here.