Investigation into the experimental kinetic support of the two-state model of the cell cycle

Cell Biophysics
J Nedelman, S I Rubinow

Abstract

Five previously published cell generation-time distribution functions have been examined in an effort to elucidate the parameters of the two-state model of the cell cycle. These parameters are the fractional number of cells that bypass the G0 state, the probability of exit from G0, and the distribution of traversal times through the active state. To explain observed beta-curve behavior of cell populations, it is necessary to define the parameters in terms of pairwise behavior of newborn sister cells. From the beta-curve, we demonstrate that at least 50% of the cells must pass through the G0 state. The alpha-curve is consistent with any positive fraction of newborn cells passing through the G0 state, and provides no further information. We explore a possible method for resolving the remaining indeterminacy regarding the number of cells bypassing the G0 state, namely, examination of the generation-time distribution functions of fast sister cells only. Such an approach, although theoretically attractive, presents formidable experimental difficulties, however. If it should turn out that indeed only 50% of the cells are apparently passing through a random-exiting phase of the cell cycle, then an alterative plausible biological mecha...Continue Reading

References

Jun 1, 1977·Journal of Cellular Physiology·R Shields, J A Smith
Jun 20, 1978·Journal of Theoretical Biology·R A Krasnow
Mar 1, 1975·Journal of Theoretical Biology·P A FantesA E Wheals
Apr 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·J A Smith, L Martin
Apr 1, 1969·Journal of Theoretical Biology·J L Lebowitz, S I Rubinow
Feb 1, 1959·Experimental Cell Research·D M PRESCOTT
Oct 1, 1962·British Journal of Haematology·L G LAJTHAC W GURNEY
Dec 1, 1962·Experimental Cell Research·J R COOK, B COOK
Feb 28, 1964·Annals of the New York Academy of Sciences·L G LAJTHAR ALEXANIAN
Apr 1, 1965·Experimental Cell Research·K B DAWSONE O FIELD
May 1, 1965·The Journal of Cell Biology·J E Sisken, L Morasca

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Citations

Jul 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·T Kuczek, D E Axelrod
Jan 1, 1987·Journal of Mathematical Biology·J NedelmanP Pharr
Jan 1, 1983·Bulletin of Mathematical Biology·A Bertuzzi, A Gandolfi
Nov 1, 1984·Cell and Tissue Kinetics·Z DarzynkiewiczM Kimmel
Jan 1, 1985·Cell and Tissue Kinetics·M Kimmel, F Traganos
Sep 21, 2005·Journal of Theoretical Biology·Leonid HaninAndrei Yakovlev

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