Investigation into the inhibitory effect of flurofamide on animal ureaplasmas and its use in the treatment of ureaplasma-infected sheep

Journal of Veterinary Pharmacology and Therapeutics
H J Ball, W J McCaughey

Abstract

In vitro tests with the urease inhibitor flurofamide demonstrated that the final inhibitory concentration of 0.5-4 microM on the growth of nine ureaplasma strains was largely ureaplasmastatic, requiring prolonged incubation to have a ureaplasmacidal effect. Intramuscular injection of flurofamide successfully eliminated genital infections of ureaplasma in sheep only when the treatment was repeated on two consecutive days. A dose rate of 5-20 mg/kg body weight eliminated the organism from naturally infected sheep, but 15-25 mg/kg body weight was required to eliminate the infection from eleven of fourteen experimentally, newly infected sheep. Administration of the flurofamide orally in the drinking water failed to eliminate ureaplasmas from any of twenty newly infected sheep.

References

Jan 1, 1978·The Journal of Antimicrobial Chemotherapy·R T Evans, D Taylor-Robinson
Feb 26, 1977·The Veterinary Record·P A Doig, H L Ruhnke
Oct 1, 1977·Journal of Bacteriology·G E Kenny, F D Cartwright
May 1, 1986·The British Veterinary Journal·H J Ball, W J McCaughey
Nov 1, 1972·Antimicrobial Agents and Chemotherapy·D K Ford
Jul 1, 1966·Journal of Bacteriology·R H PurcellR M Chanock
Jan 1, 1984·Critical Reviews in Microbiology·I J Rosenstein, J M Hamilton-Miller
Dec 1, 1984·The Journal of Antimicrobial Chemotherapy·P M FurrC M Hetherington
May 1, 1984·The British Veterinary Journal·H J Ball, W J McCaughey
Jun 19, 1982·The Veterinary Record·H J Ball, W J McCaughey
Sep 1, 1982·The Journal of Antimicrobial Chemotherapy·D Taylor-Robinson, P M Furr

❮ Previous
Next ❯

Citations

Oct 1, 1988·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·J A Robertson
Jun 1, 1987·Epidemiology and Infection·H J BallJ N Campbell
Feb 27, 2019·EFSA Journal·UNKNOWN EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)Alberto Mantovani
Mar 1, 1991·Infection and Immunity·J V Ligon, G E Kenny

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.