PMID: 11933113Apr 5, 2002Paper

Investigation into the toxicological effects of Catha edulis leaves: a short term study in animals

Phytotherapy Research : PTR
M Al-MamaryM Baker

Abstract

In this study the short term (3 months) toxicological effects of varying levels of Catha edulis leaves were examined on the plasma concentration of liver enzymes and the histopathology of tissue sections of various organs including the liver, kidneys, spleen and testis. Both the biochemical and histopathological data demonstrated, initial signs of Catha edulis toxicity. Our results show a significant increase in plasma levels of alkaline phosphatase (ALP) and alanine aminotransferase (ALT) with all levels of Catha edulis leaves tested and throughout the treatment period. The increase of ALP was more prominent than that of ALT. The plasma levels of aspartate aminotransferase (AST) were only moderately increased at the higher dose (30%) in the later stages of treatment. In addition, a time-dependent gradual increase in indirect bilirubin with a concomitant decrease in direct bilirubin levels was observed with the 30% Catha edulis with no signs of haemolysis. The histopathology of tissue sections of the liver displayed evidence of congestion of the central liver veins as well as acute hepatocellular degenerative and regenerative activities in the tissue sections obtained from animals treated with both 20% and 30% Catha edulis. Sim...Continue Reading

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Aug 31, 2002·Phytotherapy Research : PTR·Ahmed Al-MotarrebKenneth J Broadley
Nov 12, 2002·Journal of Ethnopharmacology·Molham Al-HaboriM Baker
Jun 6, 2003·Journal of Ethnopharmacology·Félix Carvalho
May 22, 2009·Journal of Psychoactive Drugs·Rita Annoni ManghiDaniele Fabio Zullino
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Feb 22, 2014·BMC Complementary and Alternative Medicine·Zewdneh Shewamene, Ephrem Engidawork
Oct 19, 2010·Evidence-based Complementary and Alternative Medicine : ECAM·Hind LakmichiKenza Loutfi
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May 14, 2008·Substance Use & Misuse·Manuela GrazianiPaolo Nencini
Nov 1, 2005·Expert Opinion on Drug Safety·Molham Al-Habori
Mar 30, 2004·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Roman J NielenWillem M A Verhoeven
Jan 16, 2009·The Journal of Sexual Medicine·Hesham Abdul AzizYvonne Tze Fung Tan
Nov 8, 2015·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Alana F PiresAna Maria S Assreuy
Sep 14, 2010·Journal of Ethnopharmacology·Susan Beckerleg
May 11, 2010·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Noam YaromMeir Gorsky
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