Copies of death certificates were provided by the Registrar General for all deaths attributed to asthma in persons aged 5 to 34 years which were registered in England and Wales in the last quarter of 1966 and the first quarter of 1967. Information was obtained from the relevant general practitioners about 177 of the 184 subjects, and necropsy data were obtained for 113 of the 124 cases in which a post-mortem examination was known to have been made. Ninety-eight per cent. of the subjects for whom evidence was obtained were known to have been suffering from asthma, and signs of severe asthma (overdistended lungs and small bronchi plugged with mucus) were found in 91% of necropsies (57% of all deaths). Evidence that death might have been due to any other pathological condition was rare. Death was sudden and unexpected in 81% of the subjects (137 out of 171), and 59% of all deaths were referred to coroners. In 39% of cases (67 out of 171) the practitioner had not regarded the patient as suffering from severe asthma in his terminal episode. Corticosteroids and sympathomimetic preparations were the only drugs to have been used by a large proportion of patients. Two-thirds of the patients had received corticosteroids before the termin...Continue Reading
Influence of short- and long-term inhalation of salbutamol on lung function and beta 2-adrenoceptors of mononuclear blood cells in asthmatic children
Dose-response effects and time course of effects of inhaled fenoterol on respiratory mechanics and arterial oxygen tension in mechanically ventilated patients with chronic airflow obstruction
Pulmonary and systemic circulatory effects and -adrenergic selectivity of hexoprenaline, salbutamol, oxyfedrine, and isoproterenol
Effect of pretreatment with bronchodilator drugs on in vitro responsiveness of guinea pig lung adenylate cyclase
Involvement of arachidonic acid metabolites in beta-adrenoceptor desensitization: functional and biochemical studies
Intramyocardial diversion of coronary blood flow: effects of isoproterenol-induced subendocardial ischemia
Deaths from asthma in Italy (1974-1988): is there a relationship with changing pharmacological approaches?
Tolerance to sympathomimetic bronchodilators in guinea-pig isolated lungs following chronic administration in vivo
Investigation of occurrence of tolerance to bronchodilator drugs in chronically pretreated guinea-pigs
Identification of adverse reactions to new drugs. II--How were 18 important adverse reactions discovered and with what delays?
National audit of acute severe asthma in adults admitted to hospital. Standards of Care Committee, British Thoracic Society
Lack of evidence for beta-2 receptor selectivity: a study of metaproterenol, fenoterol, isoproterenol, and epinephrine in patients with asthma
The lymphocyte beta-adrenoceptor in normal subjects and patients with bronchial asthma: the effect of different forms of treatment on receptor function
Cardiac arrhythmias during routine tests of pulmonary function in patients with chronic obstruction of airways
An electrocardiographic pattern of acute myocardial infarction associated with excessive use of aerosolized isoproterenol
The Salmeterol Multicenter Asthma Research Trial: a comparison of usual pharmacotherapy for asthma or usual pharmacotherapy plus salmeterol
Impact of preventive treatment with long-acting beta(2)-adrenergic agonists and inhaled corticosteroids on the morbidity and mortality of severe asthma exacerbations in 1543 patients
Changes in beta 2-adrenoceptor and other signaling proteins produced by chronic administration of 'beta-blockers' in a murine asthma model
Acute severe asthma: factors that influence hospital referral by the general practitioner and self-referral by the patient
Adverse effects and complications of treatment with beta-adrenergic agonist drugs. Committee on drugs, the American Academy of Allergy and Immunology
Ketotifen inhibits exacerbation of allergic airway hyperreactivity by racemic salbutamol in the guinea pig
Comparison of the cardiopulmonary effects of subcutaneously administered epinephrine and terbutaline in patients with reversible airway obstruction
A comparison of the death rates from asthma 1953-67 for the age groups 10-14, 15-19, and 20-24 in England and Wales with those for the same age groups in Sweden. Why have mortality rates for asthma, particularly in the mid-1960s, been higher in England and Wales than in Sweden?
A method for culturing canine tracheal smooth muscle cells in vitro: morphologic and pharmacologic observations
Analysis of the Indacaterol-Regulated Transcriptome in Human Airway Epithelial Cells Implicates Gene Expression Changes in the Adverse and Therapeutic Effects of β2 -Adrenoceptor Agonists
Should corticosteroids be used in the treatment of acute, severe asthma? II. A case against the use of corticosteroids in acute, severe asthma
Pharmaceutical excipients. Adverse effects associated with 'inactive' ingredients in drug products (Part II)
The ambient air, the good of it and the bad of it: the development of therapeutic gases and air pollution
This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.
Allergy and Asthma
Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.