PMID: 5317526Feb 10, 1968

Investigation into use of drugs preceding death from asthma

British Medical Journal
F E SpeizerL B Strang

Abstract

Copies of death certificates were provided by the Registrar General for all deaths attributed to asthma in persons aged 5 to 34 years which were registered in England and Wales in the last quarter of 1966 and the first quarter of 1967. Information was obtained from the relevant general practitioners about 177 of the 184 subjects, and necropsy data were obtained for 113 of the 124 cases in which a post-mortem examination was known to have been made. Ninety-eight per cent. of the subjects for whom evidence was obtained were known to have been suffering from asthma, and signs of severe asthma (overdistended lungs and small bronchi plugged with mucus) were found in 91% of necropsies (57% of all deaths). Evidence that death might have been due to any other pathological condition was rare. Death was sudden and unexpected in 81% of the subjects (137 out of 171), and 59% of all deaths were referred to coroners. In 39% of cases (67 out of 171) the practitioner had not regarded the patient as suffering from severe asthma in his terminal episode. Corticosteroids and sympathomimetic preparations were the only drugs to have been used by a large proportion of patients. Two-thirds of the patients had received corticosteroids before the termin...Continue Reading

References

Feb 10, 1968·British Medical Journal·F E SpeizerP Heaf

Citations

Jan 1, 1975·Journal of Clinical Pharmacology·D M Aviado
Jan 1, 1971·Pflügers Archiv : European journal of physiology·K TurnheimO Kraupp
Jan 1, 1996·Clinical Reviews in Allergy & Immunology·J Morley
Apr 7, 1977·European Journal of Pharmacology·J S DouglasA Bouhuys
Jan 1, 1982·Pharmacology & Therapeutics·T J Clark
Jan 1, 1984·Pharmacology & Therapeutics·R L Juliano
Jan 1, 1982·International Journal of Immunopharmacology·W J WieczorekE S Assem
Jan 1, 1977·General Pharmacology·R D BuñagE J Walaszek
Aug 9, 2006·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·John Oppenheimer
Nov 9, 1972·The New England Journal of Medicine
Apr 5, 1973·The New England Journal of Medicine·R K Bergner, A Bergner
Mar 20, 1975·The New England Journal of Medicine·F E SpeizerA Ramirez
Feb 13, 1986·The New England Journal of Medicine·S R Benatar
Sep 19, 1996·The New England Journal of Medicine·P M O'Byrne, H A Kerstjens
Jul 1, 1975·Archives of Environmental Health·G J Taylor
Mar 1, 1976·Archives of Environmental Health·W J Hayes
May 1, 1984·Archives of Environmental Health·K D Rosenman
Jun 1, 1974·British Journal of Clinical Pharmacology·G M ShenfieldO Ijaduola
Dec 1, 1975·British Journal of Clinical Pharmacology·C S MayJ W Paterson
Feb 1, 1992·British Journal of Clinical Pharmacology·B J Lipworth, D G McDevitt
Oct 1, 1991·Australian and New Zealand Journal of Medicine·R BeasleyC Burgess
May 1, 1969·British Journal of Pharmacology·J M CollinsJ G Swanton
Mar 1, 1971·British Journal of Pharmacology·L LohM K Sykes
Nov 1, 1972·British Journal of Pharmacology·M E ConollyM Sandler
Mar 1, 1974·British Journal of Pharmacology·D G McDevittJ G Swanton
Mar 1, 1976·British Journal of Pharmacology·A A Anderson, G M Lees
Jan 1, 1996·Pharmacology & Toxicology·N Svedmyr, C G Löfdahl
Apr 1, 1970·Archives of Disease in Childhood·J A Kuzemko, J G Lines
Aug 1, 1979·Archives of Disease in Childhood·S A McKenzieS Godfrey
Feb 15, 1969·British Medical Journal·V H Springett
Jan 15, 1972·British Medical Journal
Feb 19, 1972·British Medical Journal
Apr 5, 1969·British Medical Journal·I Gregg, J C Batten
Apr 12, 1969·British Medical Journal·R Doll
Jan 1, 1983·British Medical Journal·R P Beekman
Oct 22, 1983·British Medical Journal·P Howard
Jul 27, 1968·British Medical Journal·F E Speizer, R Doll
Oct 3, 1990·BMJ : British Medical Journal·B Dixon
Nov 25, 1972·British Medical Journal
Oct 20, 1973·British Medical Journal·B Spilker
Sep 1, 1987·Journal of Epidemiology and Community Health·M L Burr
May 1, 1977·British Journal of Industrial Medicine·F ValićM Hećej
May 1, 1969·Postgraduate Medical Journal·K N Palmer
Mar 1, 1984·Postgraduate Medical Journal·M R Hetzel
Jan 1, 1985·Postgraduate Medical Journal·P N JamesG M Cochrane
Mar 1, 1969·Thorax·G M Sterling, J C Batten
Feb 1, 1979·Thorax·D Bellamy, J V Collins
Nov 1, 1981·Thorax·P F JenkinsA P Smith
Feb 1, 1994·American Journal of Respiratory and Critical Care Medicine·W M VollmerA S Buist
Jul 1, 1971·The Journal of Clinical Investigation·G J TaylorM D Bogdonoff
Dec 21, 2005·Drugs & Aging·Pranoy Barua, M Sinead O'Mahony
Mar 10, 2001·Clinical Pharmacokinetics·David W Boulton, J Paul Fawcett
Nov 1, 2011·Drugs·Satya Mysore, Richard E Ruffin
Jan 7, 1995·Lancet·G J Blauw, R G Westendorp
Jul 24, 2014·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Kurt NikanderJohn Pritchard
Jan 1, 1984·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·M S Friedman
Jan 1, 1995·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·S LeSon, M E Gershwin
Jan 1, 1996·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·S LeSon, M E Gershwin
Jan 1, 1982·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·J F Dirks, R A Kinsman
Mar 30, 2010·Pharmaceuticals·Giovanni BarisioneVito Brusasco
Sep 1, 2008·Expert Review of Clinical Pharmacology·John J Lima
Jul 5, 2005·Expert Opinion on Investigational Drugs·D A HandleyL Vaickus
Sep 1, 1969·The Journal of Asthma Research·C Collins-WilliamsC Lamenza
Jul 5, 2005·Expert Opinion on Investigational Drugs·D A Handley, J Morley
Jan 1, 1974·Current Medical Research and Opinion·J A ChaiebF J Prime
Mar 1, 1971·The Journal of Asthma Research·A Silverglade
Jan 1, 1991·Annals of the New York Academy of Sciences·J Bousquet, F B Michel
Aug 18, 2009·The Journal of Pediatrics·Kevin J DombkowskiSarah J Clark
Aug 21, 2007·Pulmonary Pharmacology & Therapeutics·Nicola A HananiaRichard A Bond
Aug 8, 2007·Pharmacology & Therapeutics·Richard A BondClive P Page
Sep 2, 2006·Pharmacotherapy·H William Kelly
Nov 14, 1986·The American Journal of Medicine·D W Cugell
Apr 1, 1982·British Journal of Diseases of the Chest·I W Grant
Apr 1, 1982·British Journal of Diseases of the Chest·A G ArnoldE Zapata
Apr 1, 1983·British Journal of Diseases of the Chest·A G ArnoldE Zapata
Apr 1, 1971·British Journal of Diseases of the Chest·P M FraserN M Mann
Apr 1, 1984·British Journal of Diseases of the Chest·A G Chappell
Sep 1, 1987·The Journal of Allergy and Clinical Immunology·F E Speizer
Sep 1, 1987·The Journal of Allergy and Clinical Immunology·P G Burney
Sep 1, 1987·The Journal of Allergy and Clinical Immunology·J BousquetF B Michel
Aug 1, 1985·The Journal of Allergy and Clinical Immunology·T J Clark
Apr 1, 1976·The Journal of Allergy and Clinical Immunology·J Grossman
Jun 1, 1975·American Heart Journal·T WinsorH J Berger
Dec 1, 1978·Preventive Medicine·P D Stolley, R Schinnar
Dec 1, 1971·The American Journal of Medicine·A S Rebuck, J Read
Jan 1, 1980·Journal of Molecular and Cellular Cardiology·J SengesW Kübler
Jul 1, 1989·Forensic Science International : Synergy·I Morild, J C Giertsen
Jan 14, 2004·Archivos de bronconeumología·G J RodrigoL J Nannini
Apr 1, 1988·Annals of Emergency Medicine·R CydulkaJ Mathews
Apr 1, 1993·The Journal of Allergy and Clinical Immunology·K HoshikoJ Morley
Jan 1, 1976·Pharmacology & Therapeutics. Part B: General & Systematic Pharmacology·R Marshall
Jan 1, 1995·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·S LeSon, M E Gershwin
Apr 1, 1993·Respiratory Medicine·C E ClarkJ A Siddorn
Oct 10, 2007·Respiratory Medicine·J C VirchowP J Barnes
Apr 1, 1976·Acta Allergologica·V Graff-Lonnevig, S Kraepelien
Nov 20, 1975·Nature·P N BennettD S Davies
Oct 30, 2008·The Annals of Pharmacotherapy·Andrea M ChenPatrick M Finnegan
Aug 1, 1976·Clinical Pediatrics·D W Wood, H J Lecks
Jan 22, 2002·Pediatric Pulmonology·D SlatteryA A Colin
Mar 21, 1998·Chirality·D A HandleyJ Morley
Mar 12, 1971·Nature·M B YoudimM Sandler
Jul 1, 1991·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·N PearceR Beasley
Jan 1, 1984·Thorax·S W Clarke, S P Newman
Feb 1, 1977·Anaesthesia and Intensive Care·O F JamesK M Allen
Oct 2, 1986·The New England Journal of Medicine·M T Newhouse, M B Dolovich
Apr 23, 1987·The New England Journal of Medicine
Jan 1, 1970·Acta Paediatrica Scandinavica. Supplement·B Kjellman
Jan 1, 1969·Acta Medica Scandinavica·E I IisaloE J Tala
Jan 15, 2004·American Journal of Respiratory Medicine : Drugs, Devices, and Other Interventions·David W Boulton, J Paul Fawcett
May 1, 1988·Medical Toxicology and Adverse Drug Experience·L K GolightlyB H Rumack
Oct 1, 1980·British Journal of Clinical Pharmacology·R A TaralaJ W Paterson
Nov 1, 1972·British Journal of Pharmacology·E S Assem, J J Feigenbaum
May 21, 2010·Clinical Pharmacology and Therapeutics·S T Weiss
Mar 23, 1979·Virchows Archiv. A, Pathological Anatomy and Histology·H Lüchtrath
Jul 1, 1986·Medical Toxicology·K M LulichJ W Paterson
Apr 1, 1984·Scottish Medical Journal·J M Wilson
Mar 7, 2007·Annals of Saudi Medicine·B M Al Riyami, A S Dissanayake
Jul 1, 1974·Scottish Medical Journal·Y F Choo-KangI W Grant
Oct 29, 2003·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Dolores QuiñonesMiguel Delgado-Rodríguez
Jul 20, 1987·The Medical Journal of Australia·J W Paterson, A W Musk

Related Concepts

Adrenal Cortex Hormones
Aerosol Dose Form
Asthma
Broncholytic Effect
Sudden Death

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.