Investigation of a combined arteriolar dilator and beta-adrenoceptor antagonist (SK & F 92657) in the peripheral vessels of man

British Journal of Clinical Pharmacology
J G Collier, D W Pitcher

Abstract

1 SK & F 92657 is a new compound which in animals has both precapillary vasodilator and beta-adrenoceptor blocking activity. The effects of the drug on forearm blood flow and dorsal hand vein distensibility have been studied in healthy volunteers. 2 Forearm blood flow was measured by venous occlusion plethysmography. The drug was infused directly into a brachial artery. The effects of SK & F 92657 on resting flow and on the dose-response relationship for intra-arterial isoprenaline were studied. 3 Venous distensibility was measured in the large veins on the back of the hand. The drug was infused directly into a selected vein and its effects on resting tone and on the responses to noradrenaline and to isoprenaline were investigated. 4 Intra-arterial infusion of SK & F 92657 over 2 min caused a dose-dependent increase in forearm blood flow which developed gradually to reach a maximum after approximately 40 min. Infusion into dorsal hand veins at 100 ng/min and 500 ng/min had no dilator effect in veins preconstricted with noradrenaline. At higher doses SK & F 92657 potentiated the constrictor effect of noradrenaline. 5 In both veins and arteries SK & F 92657 attenuated the dilator effects of isoprenaline. The drug had no effect on...Continue Reading

References

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Citations

Jan 1, 1986·Clinical and Experimental Pharmacology & Physiology·J F Marwood, G S Stokes
Jan 1, 1985·Clinical and Experimental Hypertension. Part A, Theory and Practice·M I SteinbergK G Bemis
Jun 25, 2016·Sensors·Caroline LossRita Salvado
Jan 24, 2007·Helicobacter·Schlioma ZaterkaWolfgang Rothstein
Mar 1, 1984·British Journal of Clinical Pharmacology·P L MaliniE Ambrosioni
Oct 1, 1981·British Journal of Clinical Pharmacology·W M EdmonstoneW L Burland
May 1, 1982·British Journal of Clinical Pharmacology·D W PitcherJ R Trounce
Dec 1, 1983·British Journal of Clinical Pharmacology·W M EdmondstoneD M Denison

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