Investigation of a pre-clinical mandibular bone notch defect model in miniature pigs: clinical computed tomography, micro-computed tomography, and histological evaluation

Journal of the Korean Association of Oral and Maxillofacial Surgeons
Patricia L CarlislePamela R Brown Baer

Abstract

To validate a critical-size mandibular bone defect model in miniature pigs. Bilateral notch defects were produced in the mandible of dentally mature miniature pigs. The right mandibular defect remained untreated while the left defect received an autograft. Bone healing was evaluated by computed tomography (CT) at 4 and 16 weeks, and by micro-CT and non-decalcified histology at 16 weeks. In both the untreated and autograft treated groups, mineralized tissue volume was reduced significantly at 4 weeks post-surgery, but was comparable to the pre-surgery levels after 16 weeks. After 16 weeks, CT analysis indicated that significantly greater bone was regenerated in the autograft treated defect than in the untreated defect (P=0.013). Regardless of the treatment, the cortical bone was superior to the defect remodeled over 16 weeks to compensate for the notch defect. The presence of considerable bone healing in both treated and untreated groups suggests that this model is inadequate as a critical-size defect. Despite healing and adaptation, the original bone geometry and quality of the pre-injured mandible was not obtained. On the other hand, this model is justified for evaluating accelerated healing and mitigating the bone remodeling ...Continue Reading

References

Jan 1, 1990·The Journal of Craniofacial Surgery·J O Hollinger, J C Kleinschmidt
Feb 7, 2002·International Journal of Oral and Maxillofacial Surgery·A RachmielM Peled
Aug 23, 2002·International Journal of Oral and Maxillofacial Surgery·J P M FennisJ A Jansen
Jul 5, 2003·Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery·Andreas GrögerMichael Sittinger
May 4, 2004·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Haru AbukawaMaria J Troulis
Oct 14, 2004·Mund-, Kiefer- und Gesichtschirurgie : MKG·K-O HenkelV Bienengräber
Mar 3, 2005·International Journal of Oral and Maxillofacial Surgery·M Abu-SerriahJ Barbenel
Dec 20, 2005·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Frank P StrietzelPeter A Reichart
Feb 21, 2006·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·David GerardMykle Jacobs
May 23, 2006·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Mobolanle Olugbenga OgunleweWasiu Lanre Adeyemo
Oct 21, 2006·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Kai-Olaf HenkelVolker Bienengräber
Mar 6, 2007·European Cells & Materials·A I PearceS G Pearce
Mar 21, 2007·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·David GerardMykle Jacobs
Sep 8, 2007·International Journal of Oral and Maxillofacial Surgery·A AyoubE Odell
Feb 28, 2008·The Journal of Trauma·Brett D OwensJohn B Holcomb
Sep 2, 2008·International Journal of Oral and Maxillofacial Surgery·N Ihan Hren, M Miljavec
Feb 13, 2009·Biomaterials·Johannes C ReichertDietmar W Hutmacher
Sep 5, 2009·Journal of Tissue Engineering and Regenerative Medicine·Jin-Ling MaFu-Zhai Cui
Sep 29, 2009·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Baerbel RueheKatja Nelson
Nov 26, 2009·Journal of Clinical Periodontology·Fridus Van der WeijdenDagmar Else Slot
Dec 17, 2009·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Timothy A LewRobert G Hale
Feb 13, 2010·American Journal of Preventive Medicine·Timothy A Mitchener, Michelle Canham-Chervak
Mar 2, 2012·Clinical Implant Dentistry and Related Research·Richard J MironDaniel Buser
Aug 7, 2012·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Vladimir PetrovicVladisav Stefanovic
Aug 30, 2012·Nature Methods·Caroline A SchneiderKevin W Eliceiri
Apr 10, 2013·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Ibrahim E ZakharyMohammed E Elsalanty
Dec 3, 2013·Craniomaxillofacial Trauma & Reconstruction·Pamela R Brown BaerColonel Robert G Hale
Jan 15, 2014·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Wei LiuLai Gui

❮ Previous
Next ❯

Citations

Jan 13, 2018·Journal of Tissue Engineering and Regenerative Medicine·Shuying HuHockin H K Xu
Apr 11, 2018·Journal of Biomedical Materials Research. Part a·Tanmay P GharatMariah S Hahn
Sep 29, 2018·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Patricia CarlislePamela R BrownBaer
May 21, 2019·Journal of the Korean Association of Oral and Maxillofacial Surgeons·Patricia L CarlislePamela R Brown Baer

❮ Previous
Next ❯

Methods Mentioned

BETA
dissection
scanning electron microscopy
chips
xenografts

Software Mentioned

Systat
CTAn
NRecon
Photoshop
DataViewer
SigmaPlot
ImageJ
Vitrea Core

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.