Investigation of a role for ghrelin signaling in binge-like feeding in mice under limited access to high-fat diet

Neuroscience
S J KingA Abizaid

Abstract

Binge eating is defined by the consumption of an excessive amount of food in a short time, reflecting a form of hedonic eating that is not necessarily motivated by caloric need. Foods consumed during a binge are also often high in fat and/or sugar. Ghrelin, signaling centrally via the growth-hormone secretagogue receptor (GHSR), stimulates growth hormone release and appetite. GHSR signaling also enhances the rewarding value of palatable foods and increases the motivation for such foods. As ghrelin interacts directly with dopaminergic reward circuitry, shown to be involved in binge eating, the current studies explored the role of GHSR signaling in a limited access model of binge eating in mice. In this model, mice received either intermittent (INT) or daily (DAILY) access to a nutritionally complete high-fat diet (HFD) for 2h late in the light cycle, alongside 24-h ad libitum chow. In CD-1 mice, 2-h exposure to HFD generated substantial binge-like intake of HFD, as well as a binge-compensate pattern of 24-h daily intake. INT and daily groups did not differ in 2-h HFD consumption, while INT mice maintained stable intake of chow despite access to HFD. GHSR knock-out (KO) and wild-type (WT) mice both binged during HFD access, and e...Continue Reading

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Citations

Nov 5, 2016·Neuropharmacology·M Carmen Blanco-GandíaMarta Rodríguez-Arias
Dec 28, 2016·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S SirohiJ F Davis
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Aug 27, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Emanuela Micioni Di BonaventuraMaria Vittoria Micioni Di Bonaventura

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