PMID: 510320Nov 1, 1979

Investigation of accelerated metabolic function in small for gestational age infants

European Journal of Pediatrics
H B von Stockhausen, M Struve

Abstract

Small for gestational age (SGA) infants are known to develop relatively mild transient hyperbilirubinaemia, especially in comparison with premature infants. This may be interpreted as an index of accelerated maturation of particular vital functions. In the present study 12 SGA infants, 12 appropriate for gestational age (AGA) infants, and 12 premature infants had 24 h urine collections under standardized conditions on the third day of life. Urinary excretion of D-glucaric acid and creatinine, which can be increased by drugs (e.g. phenobarbital), were estimated. Haematocrit and bilirubin were determined at the age of 72h. In the 3 groups, the SGA infants had the highest mean haematocrit (SGA = 0.58, AGA = 0.5, Prem = 0.561/1) and the lowest mean bilirubin (SGA = 6.3, AGA = 8.6, Prem = 11.1 mg/dl). Despite a comparatively small urine volume (SGA = 19.6, AGA = 28.3, Prem = 37.3 ml/kg), excretion of D-glucaric acid (SGA = 0.18, AGA = 0.11, Prem = 0.06 mumol/kg) and creatinine (SGA = 101.6, AGA = 79.6, Prem = 80.2 mumol/kg) was significantly higher in the SGA infants. While the results do not provide conclusive evidence, the increased excretion of glucaric acid and creatinine associated with mild transient hyperbilirubinaemia can be...Continue Reading

References

Jan 1, 1978·The American Journal of Digestive Diseases·M CarrellaF De Ritis
Mar 18, 1977·European Journal of Pediatrics·G HeimannE Gladtke
Dec 1, 1975·The Journal of Pediatrics·C CassimosK Malaka-Zafiriu
Feb 15, 1973·American Journal of Obstetrics and Gynecology·L Gluck, M V Kulovich
Feb 28, 1974·Clinica Chimica Acta; International Journal of Clinical Chemistry·C J SimmonsR Williams
Feb 1, 1970·Pediatric Clinics of North America·G Cassady
Nov 1, 1969·American Journal of Diseases of Children·R G PinedaM M Desmond
Feb 1, 1970·Pediatric Clinics of North America·M Winick
Jan 1, 1968·Biologia Neonatorum. Neo-natal Studies·R Michaelis, V Melichar
Apr 1, 1966·American Journal of Obstetrics and Gynecology·K E Scott, R Usher
Jul 1, 1961·Journal of Biochemistry·M KAWADAY MANO
Aug 1, 1962·Archives of Disease in Childhood·B S WOODD J POWELL

Citations

Jun 6, 2009·American Journal of Respiratory and Critical Care Medicine·Indra NarangMark Rosenthal
Mar 1, 1985·Indian Journal of Pediatrics·J KishanA M Faquih

Related Concepts

Bilirubin, (4E,15E)-Isomer
Krebiozen
Calcium Saccharate Anhydrous
Hematocrit Procedure
Low Birth Weight Infant
Neonatal Prematurity

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