Investigation of adrenal and thyroid gland dysfunction in dogs with ultrasonographic diagnosis of gallbladder mucocele formation

PloS One
Kathleen M AicherJody L Gookin

Abstract

Gallbladder mucocele formation is an emerging disease in dogs characterized by increased secretion of condensed granules of gel-forming mucin by the gallbladder epithelium and formation of an abnormally thick mucus that can culminate in obstruction of the bile duct or rupture of the gallbladder. The disease is associated with a high morbidity and mortality and its pathogenesis is unknown. Affected dogs have a significantly increased likelihood of concurrent diagnosis of hyperadrenocorticism, hypothyroidism, and hyperlipidemia. Whether these endocrinopathies represent coincidental primary disease processes that exacerbate gallbladder mucocele formation in predisposed dogs or reflect a concurrent disruption of endocrine and lipid metabolism is unclear. In this study, we investigated a hypothesis that dogs with gallbladder mucocele formation would have a high prevalence of occult and atypical abnormalities in adrenal cortical and thyroid gland function that would suggest the presence of endocrine disruption and provide deeper insight into disease pathogenesis. We performed a case-control study of dogs with and without ultrasonographic diagnosis of gallbladder mucocele formation and profiled adrenal cortical function using a quanti...Continue Reading

References

Jan 1, 1976·Veterinary Pathology·L W Nelson, W A Kelly
Sep 1, 1977·Journal of Toxicology and Environmental Health·R G Geil, J K Lamar
Feb 1, 1988·Metabolism: Clinical and Experimental·T PaulL E Braverman
Dec 30, 1987·European Journal of Biochemistry·P CochauxJ E Dumont
May 1, 1968·Endocrinology·E D FurthC F Reid
Jan 1, 1965·Pathologia Veterinaria·R M KovatchL C Marcus
Jul 1, 1983·Journal of Comparative Pathology·V M LuckeP R Wotton
May 1, 1994·The Veterinary Clinics of North America. Small Animal Practice·E M KapteinD C Ferguson
Jun 1, 1993·The American Journal of Physiology·M D DuVall, S M O'Grady
Nov 1, 1995·Journal of the American Animal Hospital Association·S M NewellM O Downs
Apr 1, 1997·The American Journal of Physiology·O DevuystR Beauwens
Dec 24, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T ChinetC Housset
Mar 24, 1999·The Journal of Small Animal Practice·R M Dixon, C T Mooney
Jun 13, 2000·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·J G BessoC R Webster
Jan 9, 2001·The Veterinary Journal·V A CastilloM A Pisarev
Feb 24, 2001·Journal of the American Veterinary Medical Association·L A FrankJ W Oliver
Sep 20, 2001·Journal of the American Veterinary Medical Association·L B KantrowitzR Nichols
Sep 26, 2001·The Veterinary Clinics of North America. Small Animal Practice·P A GrahamA L Provencher-Bolliger
Feb 28, 2002·Journal of the American Veterinary Medical Association·Raymond F NachreinerMark M Bowman
Mar 29, 2003·Veterinary Dermatology·Linda A FrankJack W Oliver
Apr 19, 2003·The Journal of Biological Chemistry·Michiko SuzukiYuichi Sugiyama
Apr 25, 2003·Journal of the American Veterinary Medical Association·Sheila M F TorresDavid W Hayden
Dec 5, 2003·Veterinary Clinical Pathology·J Catharine Scott-MoncrieffKent R Refsal
May 25, 2004·Journal of the American Veterinary Medical Association·Fred S PikeCynthia R L Webster
Nov 24, 2004·Journal of the American Veterinary Medical Association·Deanna R WorleyHoward J Lawrence
Mar 4, 2005·Journal of the American Veterinary Medical Association·Kate E HillJack W Oliver
Apr 23, 2005·Toxicology and Applied Pharmacology·Nazzareno BallatoriRosemarie Marchan
Dec 6, 2006·Molecular and Cellular Biology·Antonius E van HerwaardenAlfred H Schinkel
Mar 7, 2007·Journal of Veterinary Internal Medicine·M M Diaz EspineiraH S Kooistra
Jul 4, 2007·Journal of the American Veterinary Medical Association·Ale L AguirreHollis N Erb
Jul 10, 2007·The Veterinary Clinics of North America. Small Animal Practice·Peter A GrahamRaymond F Nachreiner
Jun 4, 2008·Journal of the American Veterinary Medical Association·Romanie WalterManon Lécuyer
Jan 13, 2009·Veterinary Surgery : VS·Philipp D MayhewAnant Radhakrishnan
Feb 13, 2009·Journal of the American Veterinary Medical Association·Laura J CrewsIlze Matise
Sep 22, 2009·Nature Medicine·Torsten K RoepkeGeoffrey W Abbott
Jan 30, 2010·The American Journal of Pathology·David K MeyerholzMichael J Welsh
May 12, 2010·Veterinary Dermatology·Linda A FrankBarton W Rohrbach

❮ Previous
Next ❯

Citations

Jul 3, 2020·Journal of Veterinary Internal Medicine·Paula García San JoséMaría Dolores Pérez Alenza
Feb 7, 2021·Journal of Veterinary Internal Medicine·Crystal LindaberryJody L Gookin
Jun 23, 2021·Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere·Sina StreyJohanna Rieder
Dec 23, 2021·The Journal of Small Animal Practice·J A Jaffey

❮ Previous
Next ❯

Methods Mentioned

BETA
equilibrium dialysis
enzyme-linked
ELISA
hormone assay
biopsy

Software Mentioned

MedCalc
Aperio ImageScope
Prism
GraphPad
Definiens Architect XD
Sigma Plot12
Tissue Studio
Systat

Related Concepts

Related Feeds

Autoimmune Thyroiditis

Autoimmune thyroiditis is an inflammatory disease of thyroid gland due to autoimmune responses leading to lymphocytic infiltration of the gland. It is characterized by the presence of circulating thyroid antigen-specific T-cells and thyroid autoantibodies. Discover the latest research on autoimmune thyroiditis here.