Investigation of an XDR-Acinetobacter baumannii ST2 outbreak in an intensive care unit of a Lebanese tertiary care hospital.

Future Microbiology
Marwan OsmanMonzer Hamze

Abstract

Aim: We sought to investigate the genetic epidemiological relatedness of carbapenem-resistant Acinetobacter baumannii (CRAB) strains of a suspected outbreak in a Lebanese tertiary care hospital to implement necessary infection prevention and control measures. Methods: Twenty-eight nonduplicate CRAB isolates detected among hospitalized patients between January 2016 and July 2017 were studied by real-time polymerase chain reaction (PCR), pulsed-field gel electrophoresis and multilocus sequence typing analyses. Results: Twenty-seven isolates harbored blaOXA-23, of which one also carried blaNDM-1. The isolates distributed temporally in two presumably episodes were stratified by pulsed-field gel electrophoresis into many clusters. Although several clones have become endemic in the hospital, we have rapidly implemented appropriate infection prevention and control measures, achieving full eradication from August 2017 to November 2019. Conclusion: We have successfully investigated and controlled a polyclonal outbreak of OXA-23 producing ST2 CRAB.

References

Dec 24, 2010·Journal of Clinical Microbiology·Pilar VillalónJuan A Saez-Nieto
Jul 29, 2011·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A-P MagiorakosD L Monnet
Oct 4, 2012·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Marie KempfDidier Raoult
Jan 15, 2015·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Sofiane BakourJean-Marc Rolain
May 3, 2015·Journal of Medical Microbiology·Yumi KuboYoichi Kawata
May 26, 2016·New Microbes and New Infections·A Al AtrouniM Kempf
Jun 18, 2016·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Fatma Zohra MelloukJean Marc Rolain
Nov 5, 2016·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Ahmad Al AtrouniMarie Kempf
Nov 15, 2017·Antimicrobial Agents and Chemotherapy·Natalia BlancoUNKNOWN the CDC Epicenters Program
Jul 18, 2018·Journal of Bacteriology·Anne-Sophie GodeuxXavier Charpentier
Nov 6, 2018·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Abdalbagi Basheer BenmahmodRamdan Hassan Ibrahim
Dec 12, 2018·Infection and Drug Resistance·Mainul HaqueMuhamad Abu Bakar
Dec 16, 2018·Journal of Global Antimicrobial Resistance·Marwan OsmanMonzer Hamze
Aug 31, 2019·Future Microbiology·Rayane RafeiMonzer Hamze
Sep 8, 2019·Journal of Global Antimicrobial Resistance·Hiba Al-MirMarisa Haenni

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Citations

Jul 6, 2021·Future Microbiology·Marwan OsmanMonzer Hamze

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Methods Mentioned

BETA
electrophoresis
PCR

Software Mentioned

Gelcompare
UPGMA

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