Investigation of angiogenesis genes with anterior cruciate ligament rupture risk in a South African population

Journal of Sports Sciences
Masouda RahimA V September

Abstract

The angiogenesis-signalling pathway is a physiological response after mechanical loading to promote matrix remodelling and thereby maintain tissue homeostasis. Studies have shown increased expression of angiogenic molecules in response to loading and in ruptured ligaments. Recently, polymorphisms within the vascular endothelial growth factor A (VEGFA) and kinase insert-domain receptor (KDR) genes were associated with risk of anterior cruciate ligament (ACL) ruptures and Achilles tendinopathy in Caucasian study groups. A case-control genetic association study was conducted on 100 controls and 98 participants with surgically-diagnosed ACL ruptures; of which 51 participants reported non-contact mechanism of injury (NON). All participants were genotyped for five functional polymorphisms: VEGFA (rs699947, rs1570360, rs2010963) and KDR (rs2071559, rs1870377). Haplotypes were inferred. In the male participants, the KDR rs2071559 AG genotype was significantly over-represented (P = 0.048, OR: 1.90, 95% CI: 1.00-3.59) in the controls. Furthermore, the GG genotype was significantly under-represented in the male controls compared to the male ACL group (P = 0.018, OR: 2.77, 95% CI: 1.17-6.55) and the male NON subgroup (P = 0.013, OR: 3.26, ...Continue Reading

References

Oct 21, 1991·Nucleic Acids Research·D K Lahiri, J I Nurnberger
Jan 1, 1968·Acta Anatomica·R Scapinelli
Aug 27, 1999·Anatomy and Embryology·W Petersen, B Tillmann
Nov 17, 2001·Virchows Archiv : an International Journal of Pathology·T PufeR Mentlein
Jan 16, 2002·American Journal of Human Genetics·Daniel J SchaidGregory A Poland
Oct 18, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Robert C BrayPaul T Salo
Jun 5, 2003·Nature Medicine·Napoleone FerraraJennifer LeCouter
Oct 14, 2003·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Robert C BrayPaul T Salo
Jun 9, 2004·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Wolf PetersenThomas Pufe
Jun 15, 2005·International Journal of Obesity : Journal of the International Association for the Study of Obesity·J V SilhaL J Murphy
Jul 7, 2005·Scandinavian Journal of Medicine & Science in Sports·T PufeB N Tillmann
Oct 20, 2005·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·V B DuthonJ Ménétrey
Jan 25, 2006·Scandinavian Journal of Medicine & Science in Sports·G G MokoneM Collins
Feb 3, 2007·Bioinformatics·Juan R GonzálezVíctor Moreno
Aug 21, 2007·Journal of the American College of Cardiology·Yibo WangRutai Hui
May 2, 2008·The American Journal of Sports Medicine·Jasmine A BeyePaul T Salo
Aug 16, 2008·Pflügers Archiv : European journal of physiology·Stuart Egginton
Oct 7, 2008·Journal of Science and Medicine in Sport·Simon M GianottiLorna Bunt
Aug 6, 2009·The American Journal of Sports Medicine·Michael PosthumusMalcolm Collins
May 18, 2011·BMC Pregnancy and Childbirth·Idalia Garza-VelozMargarita L Martinez-Fierro
May 17, 2012·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Erica-Mari NellAlison V September
Feb 21, 2014·British Journal of Sports Medicine·Sasha MannionAlison V September
Aug 12, 2014·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Masouda RahimAlison V September
Jun 12, 2016·Medicine and Sport Science·Masouda RahimAlison September
Aug 19, 2016·Advances in Experimental Medicine and Biology·Alison SeptemberMalcolm Collins
Sep 16, 2016·Omics : a Journal of Integrative Biology·Masouda RahimAlison V September
Oct 11, 2016·Journal of Science and Medicine in Sport·Masouda RahimAlison V September

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Citations

Aug 28, 2020·Indian Journal of Orthopaedics·Manish ShuklaRabbind Singh Amrathlal
Feb 2, 2021·European Journal of Sport Science·Masouda RahimAlison V September

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Methods Mentioned

BETA
genotyping
PCR

Software Mentioned

R package haplo . stats
QUANTO
R R Development Core Team
SNPassoc
R packages genetics

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