Investigation of anti-Müllerian hormone concentrations in relation to natural conception rate and time to pregnancy

Reproductive Biomedicine Online
Anne-Sofie KorsholmHelene Westring Hvidman

Abstract

The objectives of this study were to investigate whether anti-Müllerian hormone (AMH) concentrations can predict pregnancy rates and time to pregnancy (TTP) in women attempting to conceive naturally/having an unplanned conception, and whether there is a lower AMH threshold compatible with natural conception. This prospective cohort study included 260 women aged 25-42 years in two subcohorts: (A) healthcare workers at Rigshospitalet (2008-2010), and (B) women consulting the Fertility Assessment and Counselling Clinic (2011-2014), Rigshospitalet, Denmark. Pregnancy rates and TTP at 2-year follow-up were stratified into AMH groups: low: < 9.5 pmol/l, intermediate: 9.5-33 pmol/l, high: > 33 pmol/l. Pregnancy rates increased with increasing AMH: 60.1% (low) versus 70.0% (intermediate) versus 78.3% (high) (P = 0.03). The highest pregnancy rate (84.1%) was seen in regular cycling women with high AMH. TTP was reduced in women with high AMH compared with intermediate or low AMH (stepwise trend test P = 0.01). Natural conceptions were observed with AMH concentrations down to 1.2 pmol/l. In conclusion, high AMH, especially in ovulatory women, was associated with higher pregnancy rates. Nonetheless, TTP reflected a large variation in fecun...Continue Reading

Citations

Nov 30, 2019·ACR Open Rheumatology·Jenny BrouwerJoop S E Laven
Jul 29, 2020·BMJ Sexual & Reproductive Health·Mei Ting LamErnest Hung Yu Ng
Oct 24, 2018·Journal of Gynecology Obstetrics and Human Reproduction·Mathilde VictoriaMichaël Grynberg

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