Investigation of antioxidant and anti-inflammatory activity of leaves of Dalbergia paniculata (Roxb)

Asian Pacific Journal of Tropical Medicine
Rao B GangaRaju A D Vijaya

Abstract

To investigate the antioxidant and anti-inflammatory activity of orally administered methanolic leaf extract of Dalbergia paniculata (D. paniculata) in Carrageenan induced inflammation in rats. In vitro antioxidant activity was evaluated for superoxide radical, Hydroxyl radical and DPPH radical scavenging activity. Three doses 200 mg/kg, 400 mg/kg and 800 mg/kg of D. paniculata were tested for anti-inflammatory activity in Carrageenan induced rat paw edema model and paw thickness was measured every one hour up to 6 h. The methanolic leaf extract of D. paniculata produced dose dependent inhibition of Superoxide radical, Hydroxyl radical and DPPH radicals. In Carrageenan induced inflammation model, all three doses produced significant percentage inhibition of rat paw edema and 800 mg/kg dose produced maximum percent inhibition of rat paw edema (47.83%) at 3h compared to control group. In the present study we found that methanolic leaf extract of D. paniculata showed good in vitro antioxidant activity and in vivo anti-inflammatory activity in rats.

References

Apr 11, 2003·Journal of Ethnopharmacology·Alessandra BracaNunziatina De Tommasi
Jun 15, 2007·International Journal of Food Sciences and Nutrition·Rita SaxenaM Raghunath
Apr 7, 2011·Journal of Ethnopharmacology·Ming-Hsing HuangGuan-Jhong Huang
Apr 1, 2011·Asian Pacific Journal of Tropical Biomedicine·T K Mohamed SaleemR Duraisami

❮ Previous
Next ❯

Citations

Jul 23, 2014·BMC Complementary and Alternative Medicine·Glauco Morales, Adrián Paredes

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here