Investigation of associations between NR1D1, RORA and RORB genes and bipolar disorder

PloS One
Yin-Chieh LaiPo-Hsiu Kuo

Abstract

Several genes that are involved in the regulation of circadian rhythms are implicated in the susceptibility to bipolar disorder (BD). The current study aimed to investigate the relationships between genetic variants in NR1D1 RORA, and RORB genes and BD in the Han Chinese population. We conducted a case-control genetic association study with two samples of BD patients and healthy controls. Sample I consisted of 280 BD patients and 200 controls. Sample II consisted of 448 BD patients and 1770 healthy controls. 27 single nucleotide polymorphisms in the NR1D1, RORA, and RORB genes were genotyped using GoldenGate VeraCode assays in sample I, and 492 markers in the three genes were genotyped using Affymetrix Genome-Wide CHB Array in sample II. Single marker and gene-based association analyses were performed using PLINK. A combined p-value for the joining effects of all markers within a gene was calculated using the rank truncated product method. Multifactor dimensionality reduction (MDR) method was also applied to test gene-gene interactions in sample I. All markers were in Hardy-Weinberg equilibrium (P>0.001). In sample I, the associations with BD were observed for rs4774388 in RORA (OR = 1.53, empirical p-value, P = 0.024), and rs1...Continue Reading

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Citations

Mar 16, 2017·Gene Expression Patterns : GEP·Tooka AavaniCarol Schuurmans
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Aug 6, 2020·Psychiatry Investigation·Simge Seren Kirlioglu, Yasin Hasan Balcioglu
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May 29, 2021·International Journal of Bipolar Disorders·Riccardo GuglielmoGregor Hasler
Nov 2, 2021·Biological & Pharmaceutical Bulletin·Hiroshi Matsuoka, Akihiro Michihara

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Methods Mentioned

BETA
chip
genotyping
Assay

Software Mentioned

Comprehensive Meta - Analysis
PLINK

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