Investigation of brain dynamics in Parkinson's disease by methods derived from nonlinear dynamics

Experimental Brain Research
V MüllerN Birbaumer

Abstract

EEGs were recorded from patients in early stages of Parkinson's disease (17 patients, 9 females) and healthy controls (12 subjects, 8 females) during rest and during execution/imagining of a complex motor task. The prediction that Parkinson's disease patients compared to controls would show more complex brain dynamics during performance of a complex motor task and imagination of the movements was confirmed by methods derived from nonlinear dynamics. In the resting state, analysis of correlation dimension of EEG time series revealed only slight topographical differences between the groups. During performance of a complex motor task, however, data from Parkinson's disease patients showed higher dimensionality than data from controls, indicating more complex EEG time series. The same difference was found when subjects did not perform any motor movements but imagined the complex movements they had just performed. The data are consistent with the hypothesis that the disturbances in Parkinson's disease result in the recruitment of superfluous cortical networks due to failed inhibition of alternative motor programs in the striatum and thus increase the complexity of cortical representation in motor conditions.

Citations

Oct 5, 2011·Annals of Biomedical Engineering·Carlos GómezRoberto Hornero
Jan 16, 2014·Cognitive Neurodynamics·Chun-Xiao HanYan-Qiu Che
Jan 5, 2002·Neurobiology of Aging·David E Vaillancourt, Karl M Newell
Feb 19, 2003·Brain Research. Cognitive Brain Research·Viktor MüllerNiels Birbaumer
Jun 20, 2012·Developmental Science·Viktor Müller, Ulman Lindenberger
Dec 29, 2015·Brain Connectivity·Josie-Anne BertrandJean-François Gagnon
Apr 17, 2003·Experimental Brain Research·Viktor MüllerFlorian Lang
Jan 31, 2006·Neuroscience Letters·Andrey P AnokhinErin Myers
Feb 16, 2018·Frontiers in Computational Neuroscience·Sorinel A OprisanAntonieta Lavin
Aug 5, 2011·PloS One·Tatiana MalashchenkoGennady Cymbalyuk
Jun 25, 2009·Physiological Measurement·B S RaghavendraJohn P John
Jul 27, 2012·Annals of the New York Academy of Sciences·Simon Little, Peter Brown

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