PMID: 3756772Nov 15, 1986Paper

Investigation of cell size and nuclear clefts as prognostic parameters in chronic lymphocytic leukemia

Cancer
A M Ghani, J R Krause

Abstract

The importance of the size and morphology of peripheral blood lymphocytes has been controversial as prognostic indicators in chronic lymphocytic leukemia (CLL). This study was initiated to specifically examine cell size and morphology with respect to presence or absence of nuclear clefts and the relative importance to survival. Eighty-seven cases of CLL that had not been previously treated were examined. Cleaved cells were considered present in significant numbers when they exceeded 5% of the circulating lymphocytes. Prognosis was not statistically significant when cell size and nuclear clefts were examined individually and in combination. This study confirms that clinical staging is the significant prognostic predictor irrespective of cell size and/or nuclear configuration.

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Citations

Oct 31, 2002·Human Psychopharmacology·Michael Maes
Jan 9, 1998·The American Journal of Surgical Pathology·M BonatoC De Wolf-Peeters
Nov 17, 2001·American Journal of Clinical Pathology·J L FraterE D Hsi
May 15, 2009·Applied Biochemistry and Biotechnology·Elena M Kirilova, Inta Kalnina
Apr 8, 1999·Leukemia & Lymphoma·A CrielC De Wolf-Peeters
Dec 30, 2003·Cytometry. Part B, Clinical Cytometry·Matthew A LunningGerald E Marti
Jan 1, 2008·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Gustavo K RohdeRobert F Murphy
Dec 1, 1993·Baillière's Clinical Haematology·E Montserrat, C Rozman
Jul 1, 1988·European Journal of Haematology·S Molica, A Alberti

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