Investigation of Chlamydia pneumoniae DNA, chlamydial lipopolisaccharide antigens, and Helicobacter pylori DNA in atherosclerotic plaques of patients with aortoiliac occlusive disease

Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology
Islam KaklikkayaFahri Ozcan

Abstract

It has been suggested that chronic infections may have a role in both the initiation and progression of atherosclerosis. While the majority of available data are focused on coronary artery disease, our aim was to investigate the presence of Chlamydia pneumoniae and Helicobacter pylori in samples from aortoiliac occlusive disease. Aorta-iliac atherectomy specimens were collected under sterile conditions from 21 patients (19 male, 2 female) undergoing surgery for aortoiliac occlusive disease. Seventeen macroscopically healthy vessels (12 internal mammary arteries, 3 radial arteries, prepared for coronary artery bypass graft, and 2 traumatic artery specimens, one of which was a superficial femoral artery and the other was a radial artery) were used as control. Blood samples for serological assays were obtained immediately before surgery. The polymerase chain reaction (PCR) was employed to search for H. pylori and C. pneumoniae DNA in atherosclerotic plaques and healthy vessel samples. Group-specific chlamydial lipopolysaccharide (LPS) antigens in atherosclerotic plaques and in healthy vessel samples and serum IgG antibodies to chlamydial LPS were determined by using a commercially available enzyme-linked immunosorbent assay (ELISA...Continue Reading

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Citations

Jun 14, 2008·Clinical & Developmental Immunology·Natalia MiliotiErnesto Oviedo-Orta
Mar 10, 2016·International Journal of Environmental Research and Public Health·Dandan SunYuan Yuan
Jun 3, 2006·Archives of Medical Research·Mohammed AbbasFrancesco Corea
Jan 20, 2009·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Pirkka VikatmaaPekka Saikku

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