Investigation of chromosome Y loss in men with schizophrenia

Neuropsychiatric Disease and Treatment
Takashi HirataIchiro Sora

Abstract

Life expectancy is 10-20 years lower in patients with schizophrenia than in the general population. In addition, men with schizophrenia have an earlier age at onset, more pronounced deficit symptoms, poorer course, and poorer response to antipsychotic medications than women. Recent studies have indicated that loss of chromosome Y (LOY) in peripheral blood is associated with an increased risk of all-cause mortality. In order to elucidate the pathophysiology of male-specific features, we investigated the association between LOY and schizophrenia. The present study included 360 Japanese men (146 patients with schizophrenia vs 214 controls). The relative amount of Y chromosome was defined as the ratio of chromosome Y to chromosome X (Y/X ratio) based on the fluorescent signal of co-amplified short sequences from the Y-X homologous amelogenin genes (AMELY and AMELX). There was no significant difference in the frequency of LOY between the schizophrenia and control groups. However, longer duration of illness was associated with LOY after controlling for age and smoking status in the schizophrenia group (P=0.007, OR =1.11 [95% CI =1.03-1.19]). According to our results, schizophrenia may not have a remarkable effect on blood LOY; howeve...Continue Reading

Citations

Feb 6, 2020·Human Genetics·Xihan GuoXu Wang
Feb 2, 2021·Haematologica·Panagiotis Baliakas, Lars A Forsberg
Apr 28, 2021·International Journal of Legal Medicine·Qianqian PangJunfang Wang
May 15, 2021·Nature Reviews. Genetics·Alexander J SilverMichael R Savona

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Methods Mentioned

BETA
electrophoresis

Software Mentioned

GeneMapper
R
EZR

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