Investigation of "cross-tolerance" between systemic and intrathecal morphine in rats

Physiology & Behavior
C B Tyler, C Advokat

Abstract

Animals were implanted subcutaneously with morphine or placebo pellets and assessed daily on the hot plate or the tail flick test. After tolerance developed to morphine-induced analgesia the response to an acute systemic (1-6 mg/kg SC) or intrathecal morphine injection (0-30 micrograms) was determined. "Cross-tolerance" was observed on both the hot plate (6 mg/kg) and the tail flick tests (3 and 6 mg/kg) between the two different routes of subcutaneous administration. "Cross-tolerance" was also observed between systemic and intrathecal morphine on the hot plate test. However, no "cross-tolerance" between systemic and spinal morphine was observed in animals on the tail flick test. Assessment of naloxone-precipitated withdrawal indicated that morphine implanted animals showed more abstinence signs (wet shakes and teeth chattering) than placebo animals. These results suggest that the nociceptive assessment procedure plays a significant role in the expression of "cross-tolerance" between systemic and spinal opiates.

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Citations

Jul 23, 1987·European Journal of Pharmacology·C Advokat, P Burton
Jan 1, 1987·Physiology & Behavior·C AdvokatC B Tyler
Nov 1, 1989·Pharmacology, Biochemistry, and Behavior·J A Siuciak, C Advokat
Oct 5, 2007·Journal of Neurophysiology·Kevin M HellmanPeggy Mason
Aug 2, 2015·Personality and Social Psychology Review : an Official Journal of the Society for Personality and Social Psychology, Inc·Andrew P Hill, Thomas Curran
Jan 4, 2017·Neuromodulation : Journal of the International Neuromodulation Society·Timothy R DeerNagy Mekhail

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