Investigation of Differences in P53 Gene Polymorphisms between Schizophrenia and Lung Cancer Patients in the Turkish Population.

Genetics Research International
Ulku OzbeyTamer Elkiran

Abstract

Objective. The reduced incidence of cancer observed in schizophrenia patients may be related to differences in genetic background. It has been suggested that genetic predisposition towards schizophrenia is associated with reduced vulnerability to lung cancer, and p53 gene is one of the candidate genes. In our study, we aimed to investigate polymorphisms in the BstUI in exon 4 and MspI in intron 6 restriction sites of the p53 gene in Turkish schizophrenia patients, lung cancer patients, and controls. Material and Methods. Allele and genotype incidence of these polymorphisms with their haplotype combinations were studied in 100 Turkish lung cancer and schizophrenia patients and 100 controls without malignant and schizophrenia diseases. The genotype characteristics were determined by PCR-based RFLP method using DNA extracted from peripheral blood. Results. For the BstUI and MspI polymorphism, there were found significant differences in the genotype and allele frequencies between schizophrenia and lung cancer patients with control groups (P < .01). The analysis based on haplotype frequencies showed the presence of BstUI-MspI 2-1 haplotype in cancer patients (12%) in contrast to the absence of this haplotype in schizophrenia and con...Continue Reading

References

Sep 1, 1995·Carcinogenesis·R BirganderL Beckman
May 1, 1995·Human Heredity·A SjälanderG Beckman
Jun 1, 1994·Schizophrenia Research·P B Mortensen
Jun 1, 1996·Carcinogenesis·A SjälanderL Beckman
Jan 1, 1996·Annual Review of Medicine·D Sidransky, M Hollstein
Mar 1, 1997·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·A CharlouxH Kreisman
Feb 5, 1998·CA: a Cancer Journal for Clinicians·S H LandisP A Wingo
Nov 26, 1998·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·G GürselA Karalezli
Aug 17, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Y C WangC Y Chen
Feb 25, 2000·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·H SkuladottirF R Hirsch
Jun 7, 2000·Lancet·P C HoffmanE E Vokes
Sep 29, 2000·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·C LeeJ S Song
Feb 13, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C FidanerD M Parkin
Feb 13, 2001·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·E BirosJ Salagovic
Jun 29, 2001·Archives of General Psychiatry·A Jablensky, D Lawrence
Jan 30, 2002·Psychiatry Research·H J ChiuS J Tsai
Feb 10, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Adi F Gazdar, Michael J Thun

❮ Previous
Next ❯

Citations

Sep 2, 2014·Cancer Epidemiology·Bozena SmolkovaKari Hemminki
Sep 21, 2018·Frontiers in Cellular Neuroscience·Xingchun GaoXingchun Gou
Feb 28, 2019·Frontiers in Molecular Neuroscience·Chuanjun ZhuoLi Zhang

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
electrophoresis

Software Mentioned

SPSS ( Statistical Packages of Social Sciences , SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Lung Cancer : Journal of the International Association for the Study of Lung Cancer
Erik BirosJ Salagovic
European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
E MammanoD Nitti
© 2021 Meta ULC. All rights reserved