Investigation of DNA repair-related SNPs underlying susceptibility to papillary thyroid carcinoma reveals MGMT as a novel candidate gene in Belarusian children exposed to radiation

BMC Cancer
Christine LonjouFabienne Lesueur

Abstract

Genetic factors may influence an individual's sensitivity to ionising radiation and therefore modify his/her risk of developing papillary thyroid carcinoma (PTC). Previously, we reported that common single nucleotide polymorphisms (SNPs) within the DNA damage recognition gene ATM contribute to PTC risk in Belarusian children exposed to fallout from the Chernobyl power plant accident. Here we explored in the same population the contribution of a panel of DNA repair-related SNPs in genes acting downstream of ATM. The association of 141 SNPs located in 43 DNA repair genes was examined in 75 PTC cases and 254 controls from the Gomel region in Belarus. All subjects were younger than 15 years at the time of the Chernobyl accident. Conditional logistic regressions accounting for radiation dose were performed with PLINK using the additive allelic inheritance model, and a linkage disequilibrium (LD)-based Bonferroni correction was used for correction for multiple testing. The intronic SNP rs2296675 in MGMT was associated with an increased PTC risk [per minor allele odds ratio (OR) 2.54 95% CI 1.50, 4.30, Pper allele = 0.0006, Pcorr.=0.05], and gene-wide association testing highlighted a possible role for ERCC5 (PGene = 0.01) and PCNA (P...Continue Reading

References

Mar 25, 1995·BMJ : British Medical Journal·V A StsjazhkoK F Baverstock
Nov 2, 1994·Journal of the National Cancer Institute·D E GoldgarM H Skolnick
Nov 28, 2002·International Journal of Cancer. Journal International Du Cancer·Kari Hemminki, Xinjun Li
Apr 28, 2004·Current Opinion in Genetics & Development·Errol C FriedbergRoger A Schultz
May 19, 2005·Journal of the National Cancer Institute·Elisabeth CardisDillwyn Williams
Oct 11, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Susana N SilvaJorge Gaspar
Aug 8, 2006·Thyroid : Official Journal of the American Thyroid Association·Undraga SchagdarsurenginReinhard Dammann
Dec 19, 2007·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Eiwa IshidaNoboru Konishi
Dec 2, 2008·Best Practice & Research. Clinical Endocrinology & Metabolism·Dillwyn Williams
Feb 5, 2009·Thyroid : Official Journal of the American Thyroid Association·Tang HoErich M Sturgis
Mar 17, 2009·Endocrine-related Cancer·Natallia M AkulevichShunichi Yamashita
Aug 28, 2009·Cancer Letters·Elisavet GatzidouStamatios Theocharis
Sep 8, 2009·Thyroid : Official Journal of the American Thyroid Association·Cairong ZhuYawei Zhang
Oct 23, 2009·Nature·Stephen P Jackson, Jiri Bartek
Dec 31, 2009·Critical Reviews in Biochemistry and Molecular Biology·Parameswary A MuniandyMichael M Seidman
Mar 31, 2010·Human Molecular Genetics·Meiko TakahashiShunichi Yamashita
Jul 6, 2010·American Journal of Human Genetics·Jimmy Z LiuStuart Macgregor
Jul 9, 2010·CA: a Cancer Journal for Clinicians·Ahmedin JemalElizabeth Ward
Jul 24, 2010·Endocrine Reviews·Bridget SinnottArthur B Schneider
Nov 19, 2010·Nature Reviews. Genetics·Kai WangHakon Hakonarson
Mar 2, 2011·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Constantinos GiaginisStamatios Theocharis
Mar 19, 2011·Mutation Research·Wilser-Andrés García-QuispesRicard Marcos
May 26, 2011·Journal of Molecular Endocrinology·Iñigo Landa, Mercedes Robledo
Aug 28, 2012·Oncology Reports·Luís S SantosJorge F Gaspar
Oct 3, 2012·Carcinogenesis·Anthony J AlbergPaul T Strickland
May 11, 2013·Thyroid : Official Journal of the American Thyroid Association·Sandya LiyanarachchiAlbert de la Chapelle
Jun 6, 2013·Journal of Cancer Epidemiology·Gabriella PellegritiRiccardo Vigneri
Oct 10, 2013·International Journal of Cancer. Journal International Du Cancer·Francesca DamiolaAusrele Kesminiene
Oct 16, 2013·International Journal of Cancer. Journal International Du Cancer·Elena BonoraFabienne Lesueur
May 27, 2014·Frontiers in Oncology·C Elizabeth Caldon
Oct 7, 2014·International Journal of Cancer. Journal International Du Cancer·Carlo La VecchiaEva Negri
Apr 10, 2015·International Journal of Cancer. Journal International Du Cancer·Veronika MancikovaAngel Carracedo
Jul 2, 2015·Thyroid : Official Journal of the American Thyroid Association·Salvatore VaccarellaSilvia Franceschi
Feb 5, 2016·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Gisella FiglioliStefano Landi
Jun 18, 2016·Cancer Biomarkers : Section a of Disease Markers·Tereza HalkovaBela Bendlova

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Citations

May 5, 2018·Briefings in Bioinformatics·L Cristobal Monraz GomezInna Kuperstein
Apr 9, 2021·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Monia ZidaneFlorent de Vathaire

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Methods Mentioned

BETA
blood drawing
Assay
genotyping

Software Mentioned

VEGAS
GenomeStudio
PLINK

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