Investigation of enterohemorrhagic Escherichia coli O157:H7 adherence characteristics and invasion potential reveals a new attachment pattern shared by intestinal E. coli.

Infection and Immunity
M L McKee, Alison D O'Brien

Abstract

In this study, the interactions of enterohemorrhagic Escherichia coli (EHEC) O157 strains with human ileocecal (HCT-8) epithelial cells and HEp-2 cells were examined. EHEC adhered to, but did not invade, HCT-8 cells by the localized adherence mechanism and a heretofore unrecognized pattern which we called log jam. The log jam formation was (i) not observed on HEp-2 cells, (ii) independent of the EHEC eaeA gene required for localized adherence, and (iii) shared by pathogenic and nonpathogenic E. coli strains but not K-12 strains. The log jam phenotype may represent a basal means by which E. coli bacteria attach to the human intestine.

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Citations

Jun 12, 2020·Frontiers in Cellular and Infection Microbiology·Karl JohanssonDiana Karpman
Jun 29, 2011·Infection and Immunity·Mauricio J FarfanAlfredo G Torres
Jan 25, 2013·Blood Purification·Carla M Nester
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Jan 29, 2011·Microbiology and Immunology·Cheng-song WanXue-li Zheng
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