PMID: 7539248Jan 1, 1995Paper

Investigation of epidermotropism in canine mycosis fungoides: expression of intercellular adhesion molecule-1 (ICAM-1) and beta-2 integrins

Archives of Dermatological Research
T OlivryV K Affolter

Abstract

In human mycosis fungoides (MF), interactions between LFA-1 (CD11a/CD18) and ICAM-1 (CD54) are involved in lymphocyte adhesion to keratinocytes. The purpose of this study was to evaluate the expression of ICAM-1, beta-2 integrins and class II major histocompatibility complex molecules (MHC II) on keratinocytes and infiltrating lymphocytes in canine MF. Sections of frozen skin biopsy specimens from normal dogs (n = 3) and dogs with MF (n = 17) were evaluated by immunohistochemistry for expression of ICAM-1, beta-2 integrins, and class II MHC molecules. Our results demonstrated that in canine MF, ICAM-1 was expressed variably on epidermal and follicular keratinocytes. The extent of keratinocyte ICAM-1 expression did not correlate with the degree of lymphocyte epithelial infiltration, nor with lymphocyte LFA-1 expression. This was especially evident in cases of Pagetoid reticulosis-like disease in which prominent lymphocyte epidermotropism was not accompanied by keratinocyte ICAM-1 expression. Keratinocyte class II MHC molecule expression did not correlate with keratinocyte ICAM-1 expression. In conclusion, in canine MF, the lack of statistically significant correlations between epithelial lymphocyte infiltration and keratinocyte ...Continue Reading

References

Mar 1, 1992·The Journal of Investigative Dermatology·R W GrovesD M MacDonald
May 1, 1992·Journal of the American Academy of Dermatology·P HealdR Edelson
Jun 1, 1992·Journal of the American Academy of Dermatology·W H BoehnckeW Sterry
Nov 1, 1990·Tissue Antigens·P F MooreD M Danilenko
May 1, 1991·The Journal of Investigative Dermatology·E BertiR Caputo
Aug 2, 1990·Nature·T A Springer
Nov 1, 1990·World Journal of Surgery·R G Tompkins, J F Burke
Oct 1, 1987·The American Journal of Dermatopathology·B J NickoloffE C Butcher
Apr 21, 1989·JAMA : the Journal of the American Medical Association·B J NickoloffK D Cooper
Oct 1, 1989·The Journal of Investigative Dermatology·J N BarkerD M MacDonald
Jan 1, 1989·Archives of Dermatological Research·U KonterW Sterry
Mar 3, 1989·Science·J L Marx
Mar 1, 1987·The Journal of Experimental Medicine·M L DustinT A Springer
Jan 1, 1988·Annual Review of Immunology·A F Williams, A N Barclay
Dec 1, 1985·The British Journal of Dermatology·R WillemzeW M Nugteren

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Citations

Sep 1, 1996·Archives of Dermatological Research·T OlivryD K Naydan
Oct 23, 1997·The American Journal of Dermatopathology·T OlivryP F Moore
Jan 1, 1997·Veterinary Clinical Pathology·Aiden P. FosterDavid M. Vail
Sep 21, 2001·The Journal of Investigative Dermatology·K PaulsM P Schön
Jan 8, 2004·The Journal of Investigative Dermatology·Michael P SchönW Henning Boehncke
Feb 19, 2009·Veterinary and Comparative Oncology·J FontaineR S Mueller
Jun 7, 2005·Expert Opinion on Therapeutic Targets·Michael P Schön, Ralf J Ludwig
Jun 16, 2012·Veterinary Pathology·F N OliveiraI M Langohr

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