Investigation of equine influenza cases exhibiting neurological disease: coincidence or association?

Journal of Comparative Pathology
J M DalyKen C Smith

Abstract

Equine influenza is usually a transient and self-limiting disease. However, during an outbreak of equine influenza in the UK in 2003 there were reports of unusually severe clinical signs among unvaccinated animals. Two influenza-infected horses developed neurological signs, and one was subjected to euthanasia. Post-mortem examination of the brain revealed viral-type non-suppurative encephalitis, and influenza virus antigen was demonstrated by immunolabelling of sections of nasal mucosa. A syndrome known as influenza-associated encephalopathy has been described in man. Although not proved, the data suggest that similar disease mechanisms may operate in horses, and that equine influenza virus infection can result in encephalitis in the natural host, perhaps due to an aberrant host immune response.

References

Nov 1, 1993·Equine Veterinary Journal·R G Webster
Aug 23, 2003·The Journal of Infectious Diseases·Jun-ichi KawadaTsuneo Morishima
Oct 3, 2003·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·M Studahl

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Citations

May 18, 2013·Veterinary Microbiology·A Cullinane, J R Newton
Feb 5, 2010·Journal of Virology·Roberto A SaenzJulia R Gog
Mar 8, 2008·Emerging Infectious Diseases·Janet M DalyKen C Smith
Oct 6, 2014·The Veterinary Clinics of North America. Equine Practice·Gabriele A Landolt
Jan 24, 2012·The Veterinary Journal·S L Priestnall, K C Smith
Aug 6, 2010·The Veterinary Journal·Janet M DalyDebra M Elton

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