Investigation of Factors Affecting the Sensitivity of Bile Duct Brush Cytology

Internal Medicine
Masanori KobayashiTsutomu Kobatake

Abstract

Objectives While bile duct brush cytology during endoscopic retrograde cholangiopancreatography (ERCP) is a well-established procedure for detecting malignant biliary stricture, its sensitivity is reportedly low. We aimed to determine the pre-ERCP factors affecting brush cytology sensitivity. Methods We retrospectively analyzed 185 patients who underwent brush cytology during the first ERCP for undiagnosed biliary stricture at our institution between January 2014 and December 2016. We analyzed the relationship of age, sex, final diagnosis, stricture location, tumor size, stricture length, total bilirubin level, white blood cell count, and C-reactive protein level with brush cytology sensitivity. Results The following conditions were established as final diagnoses: benign disease, 19 cases (10.3%); intrahepatic cholangiocarcinoma, 10 cases (5.4%); hilar cholangiocarcinoma, 38 cases (20.5%); extrahepatic cholangiocarcinoma, 44 cases (23.8%); pancreatic cancer, 55 cases (29.7%); other malignant tumors, 19 cases (10.3%). The sensitivity and specificity of brush cytology were 60.8% and 94.7%, respectively. The stricture length, total bilirubin level, and white blood cell count in true-positive cases were significantly higher than th...Continue Reading

References

May 29, 2001·Journal of Clinical Pathology·C J StewartW R Murray
Aug 17, 2004·The American Journal of Gastroenterology·Gavin C HarewoodDiva R Salomao
Oct 13, 2006·Gastroenterology·Laura E Moreno LunaGregory J Gores
Jan 19, 2008·World Journal of Gastroenterology : WJG·Nasim MahmoudiJennifer Telford
Dec 12, 2012·Gastrointestinal Endoscopy·Michelle A AndersonBrooks D Cash
Dec 27, 2015·Gastrointestinal Endoscopy·UNKNOWN ASGE Standards of Practice CommitteeJohn M DeWitt

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Citations

Mar 4, 2021·Endoscopy International Open·Livia ArchibugiPaolo Giorgio Arcidiacono
Jul 16, 2021·Gastrointestinal Endoscopy·Varayu PrachayakulPeti Thuwajit

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Methods Mentioned

BETA
biopsy

Software Mentioned

SAS JMP
SAS

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